Di-(2-ethylhexyl) Phthalate Upregulates ATF3 Expression and Suppresses Apoptosis in Mouse Genital Tubercle
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概要
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Objectives: To investigate the effect of di-(2-ethylhexyl) phthalate (DEHP) on the expression of activating transcription factor 3 (ATF3) and apoptosis of fetal mouse genital tubercle (GT). Methods: In this developmental toxicity study, pregnant C57BL/6 mice were exposed to corn oil or DEHP (100 or 500mg/kg/day) from embryonic day 12 (ED12) to ED16. Apoptosis was characterized by Terminal transferase dUTP nick end labeling (TUNEL) assay. Using RT-PCR and western blot, the expressions of ATF3 and apoptosisrelated genes (P53, Bcl-2 and Bax) were investigated. Results: Apoptosis of fetal mouse GT cells notably decreased after DEHP treatment. DEHP activated ATF3 both at the mRNA and protein levels in GT. Furthermore, pro-apoptotic P53 was downregulated and the ratio of anti-apoptotic (Bcl-2)/pro-apoptotic (Bax) was not significantly changed. Conclusions: These results suggest that DEHP may induce external genital defects via a mechanism involving apoptosis, which might correlate with the regulation of ATF3 and P53 expressions.
- 社団法人日本産業衛生学会の論文
著者
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Liu Xing
Department Of Materials Science Graduate School Of Engineering Tohoku University
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He Da-wei
Department Of Pediatric Urology Chongqing Children's Hospital
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Lin Tao
Department Of Powder Metallurgy University Of Science And Technology Beijing
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Lin Tao
Department Of Pediatric Urology Chongqing Children's Hospital
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Liu Xing
Department Of Pediatric Urology Chongqing Children's Hospital
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Zhang De-ying
Department Of Pediatric Urology Chongqing Children's Hospital
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Wei Guang-hui
Department Of Pediatric Urology Chongqing Children's Hospital
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LI Ya-Sha
Department of Molecular Biology, Pediatric Research Institute, Chongqing Medical University
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XIONG Jing
Department of Pediatric Urology, Chongqing Children's Hospital
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LI Xu-Liang
Department of Pediatric Urology, Chongqing Children's Hospital
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Li Ya-sha
Department Of Molecular Biology Pediatric Research Institute Chongqing Medical University
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Xiong Jing
Department Of Pediatric Urology Chongqing Children's Hospital
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Liu Xing
Department Of Cardiology Beijing Anzhen Hospital Capital Medical University
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Lin Tao
Department Of Biology Hong Kong Baptist University
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