Anti-hepatitis B Virus Activities of Astragaloside IV Isolated from Radix Astragali(Pharmacology)
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概要
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Total ethanol extract and saponins from Chinese herb Radix Astragali (Huangqi) have been previously shown to possess anti-hepatitis B virus (HBV) activities in vitro. To identify the active ingredients, we isolated a triterpenoid saponin that was determined to be astragaloside IV. In the human HBV transfected liver cell line HepG_2 2.2.15, astragaloside IV effectively suppressed secretion of HBV antigens with inhibition rates of 23.6% for the secretion of Hepatitis B surface antigen (HBsAg) and 22.9% for that of Hepatitis B e antigen (HBeAg) at 100μg/ml after 9d of treatment. The inhibitory activity of astragaloside IV on secretion of HBV antigens is more potent than that of 3TC without significant cytotoxicity. In duck hepatitis B virus (DHBV)-infected ducklings, astragaloside IV caused 64.0% inhibition at 120mg/kg, 49.6% inhibition at 40mg/kg, and 41.7% inhibition at 10mg/kg to serum DHBVs after 10d of treatment, and also reduced serum DHBV DNA levels. Together, our results demonstrate that astragaloside IV possesses potent anti-HBV activity.
- 2009-01-01
著者
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Zhou Wei
中華人民共和国
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LI Bo
Department of Functional Materials, Central Iron & Steel Research Institute
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ZHOU Pei
Department of Gastroenterology and Hepatology, Kinki University School of Medicine
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Li Bo
State Key Lab. Of Phytochemistry And Plant Resources In West China Kunming Inst. Of Botany Chinese A
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Li Bo
Department Of Dermatology No. 1 Hospital Of China Medical University
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Gao Wen
Department Of Traditional Chinese Medicine Shanghai Institute Of Pharmaceutical Industry
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Zhou Pei
Department Of Biosynthesis Medicinal Chemistry School Of Pharmacy Fudan University
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Huang Hai
Department Of Biosynthesis Medicinal Chemistry School Of Pharmacy Fudan University
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WANG Shuguang
Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry
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LI Jiyang
Department of Biosynthesis Medicinal Chemistry, School of Pharmacy, Fudan University
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ZHUANG Changlong
Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry
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KONG Deyun
Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry
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Li Jiyang
Department Of Biosynthesis Medicinal Chemistry School Of Pharmacy Fudan University
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Kong Deyun
Department Of Traditional Chinese Medicine Shanghai Institute Of Pharmaceutical Industry
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Wang Shuguang
Department Of Traditional Chinese Medicine Shanghai Institute Of Pharmaceutical Industry
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Zhuang Changlong
Department Of Traditional Chinese Medicine Shanghai Institute Of Pharmaceutical Industry
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Li Bo
Department Of Biochemistry And Molecular Biology Tongji Medical College Huazhong University Of Scien
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Zhou Pei
Department of Anesthesia, The Second Xiangya Hospital of Central South University
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Gao Wen
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
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