Anti-hepatitis B Virus Activities of Geranium carolinianum L. Extracts and Identification of the Active Components(Pharmacology)

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概要

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• The ethanol extract of Geranium carolinianum L., a domestic plant grown in China, was subjected to sequential extractions with different organic solvents. The extracts were assayed for anti-hepatitis B virus (HBV) activities. The ethyl acetate fraction was found to contain the highest level of anti-HBV activity. In order to identify the active ingredients, the ethyl acetate fraction was further fractionated by column chromatography. Seven compounds were identified including ellagic acid, geraniin, quercitrin, hyperin, hirsutrin, quercetin, and kaempferol, whose structures were determined by NMR. The presence of the anti-HBV compounds geraniin, ellagic acid and hyperin in G. carolinianum L. may account for the effectiveness of this folk medicine in the treatment of HBV infections. Geraniin inhibited hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) secretion by more than 85.8% and 63.7%, respectively, at the non-cytotoxic concentration of 200 μg/ml. The inhibitions of HBsAg and HBeAg secretion by geraniin were higher than the inhibition by the positive control Lamivudine, 33.5% and 32.2% respectively, at the same concentration. Since HBeAg is involved in immune tolerance during HBV infection, the newly identified anti-HBV compound geraniin might be a candidate agent to overcome the immune tolerance in HBV-infected individuals. This is the first report of the anti-HBV effects of geraniin and hyperin, the active substances derived from G. carolinianum L.

• 公益社団法人日本薬学会の論文
• 2008-04-01

著者

• ZHOU Wei

  Departments of Cardiovascular Biology and physiology,Faculty of Medicine,University of Tokyo

• Zhou Wei

  中華人民共和国

• Zhou Wei

  Department Of Biosynthetic Medicinal Chemistry School Of Pharmacy Fudan University

• ZHOU Pei

  Department of Gastroenterology and Hepatology, Kinki University School of Medicine

• Zhou Pei

  Department Of Biosynthesis Medicinal Chemistry School Of Pharmacy Fudan University

• Huang Hai

  Department Of Biosynthesis Medicinal Chemistry School Of Pharmacy Fudan University

• LI Jiyang

  Department of Biosynthesis Medicinal Chemistry, School of Pharmacy, Fudan University

• Li Jiyang

  Department Of Biosynthesis Medicinal Chemistry School Of Pharmacy Fudan University

• FENG Meiqing

  Department of Biosynthetic Medicinal Chemistry, School of Pharmacy, Fudan University

• Feng Meiqing

  School Of Pharmacy Fudan University

• Zhuang Changlong

  Department Of Traditional Chinese Medicine Shanghai Institute Of Pharmaceutical Industry

• Zhou Wei

  Department Of Anesthesiology Huashan Hospital Fudan University

• Zhou Pei

  Department of Anesthesia, The Second Xiangya Hospital of Central South University

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