In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-β-D-glucopyranoside against Coxsackie Virus B3(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Calycosin-7-O-β-D-glucopyranoside (CCGR) is the main isoflavonoid compound isolated from Astragalus membranaceus var. Mongholicu (BGE.) HSIAO, a Chinese herb medicine traditionally used to treat viral myocarditis. In this study, its antiviral activities against coxsackie virus B3 (CVB3) causing myocarditis were investigated. In vitro assay showed that CCGR displayed a low cytotoxicity and effectively inhibited CVB3-mediated cytopathic effects on Vero cells with an IC_<50> value of 25μg/ml. In an acute myocarditis murine model, treatment with 24mg/kg CCGR for 14d significantly improved the survival rate of mice infected with CVB3, alleviated pathological damages of cardiac muscles in the myocarditis mice, reduced the virus titers in the heart, decreased heart indexes and improved left ventricular function. These results showed that CCGR exerted significant antiviral activities against CVB3 both in vitro and in vivo, and identified CCGR as one of active ingredients in Astragalus membranaceus for the treatment of viral myocarditis.
- 公益社団法人日本薬学会の論文
- 2009-01-01
著者
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Zhou Wei
中華人民共和国
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ZHOU Pei
Department of Gastroenterology and Hepatology, Kinki University School of Medicine
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Ye Guan
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Zhou Pei
Department Of Biosynthesis Medicinal Chemistry School Of Pharmacy Fudan University
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Zhou Pei
Department Of Biosynthetic Medicinal Chemistry School Of Pharmaceutical Sciences Fudan University
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Zhang Yuanyuan
Department Of Microbiology And Microbial Engineering School Of Life Science Fudan University
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ZHU Haiyan
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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LI Zhixiong
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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HUANG Chenggang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Zhu Haiyan
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences:department Of Biosynthetic Medicina
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Li Zhixiong
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Huang Chenggang
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Zhu Haiyan
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Zhou Pei
Department of Anesthesia, The Second Xiangya Hospital of Central South University
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