Syntheses and Doxorubicin-Inclusion Abilities of β-Cyclodextrin Derivatives with a Hydroquinone α-Glycoside Residue Attached at the Primary Side
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概要
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This paper describes syntheses and doxorubicin-inclusion abilities of β-cyclodextrin (CyD) derivatives with a hydroquinone α-glycoside residue attached at the primary side. The hydroquinone glycoside having an α-D-glucosidic or 2-acetamido-2-deoxy-α-D-glucosidic linkage became a useful component for providing an α-D-glucose- or 2-acetamido-2-deoxy-α-D-glucose-β-CyD conjugate. The surface plasmon resonance analyses of these β-CyD derivatives for the anticancer agent, doxorubicin, indicated that they had excellent inclusion associations on the order of 10^5M^<-1> for the immobilized doxorubicin.
- 公益社団法人日本薬学会の論文
- 2009-01-01
著者
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YAMANOI Takashi
The Noguchi Institute
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Hattori Kenjiro
Department Of Nanochemistry Faculty Of Engineering Tokyo Polytechnic University
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Hattori Kenjiro
Department Of Applied Chemistry Faculty Of Engineering Tokyo Institute Of Polytechnics
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ODA Yoshiki
The Noguchi Institute
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MIURA Masumi
The Noguchi Institute
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Miura Masumi
The Noguchi Institute:department Of Nanochemistry Faculty Of Engineering Tokyo Polytechnic Universit
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