抗MRSA薬の適正使用を目的としたICT介入の効果

概要

論文の詳細を見る
We established a reporting system for the use of antimicrobial agents for methicillin resistant Staphylococcus aureus (MRSA) infections in January 2003 to help ensure they are used properly. Then, in October 2005, we set up an infection control team (ICT) to monitor the use of four agents for MRSA infections: vancomycin, teicoplanin, arbekacin and linezolid. Changes in the antimicrobial use densities of the agents, the number of patients receiving them and the therapeutic drug monitoring (TDM) execution rate were investigated for three periods: I: before the reporting system (2002), II: while reporting system was in use (2004), III: during ICT monitoring (2006). There was no significant change in the antimicrobial use densities of the agents for MRSA infection, while the number of patients receiving them decreased significantly in period III (p<0.05). Also in period III, the antimicrobial use density of teicoplanin increased significantly (p<0.05), there was a marked decrease in the number of patients receiving vancomycin (p<0.01) and the TDM execution rate increased significantly (p<0.01). The systematic activities performed by the ICT were effective in ensuring the proper use of antimicrobial agents for MRSA infection. Further, by enabling us to share information with other medical staff and conduct rapid interventions, they have been playing an important role in infection control in our hospital.
日本医療薬学会の論文
2008-12-10