ジヒドロリポアミド・サクシニル転移酵素遺伝子の複数の転写産物(自然科学編)

概要

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We detected three truncated cDNA products transcribed from the introns 2, 13 and 14 of the dihydrolipoamide succinyltransferase (DLST) gene, respectively and report about the character of the three truncated cDNA products in present study. One truncated cDNA product started from the intron 2 of the DLST gene and contained the region covering from the exon 3 to exon!4, but did not contain the exon 15 of the DLST gene. The other one truncated cDNA product was consisted of intron 12, exon 13, intron 13, exons 14 and 15. This unique cDNA product contained the intron 13 between the exons 13 and 14. The another truncated cDNA product was composed of the intron 14 and exon 15 containing two continuous methionines and the termination condon TAG, predicting the existence of a protein consisting of 38 or 39 amino acid residues. The truncated cDNA products were also confirmed using total RNA from rat skeletal muscle by RT-PCR method. Possibly the RNA fragments participate in the control of gene expression of the DLST gene.
鹿児島女子短期大学の論文