真核生物におけるDLST遺伝子のイントロン1及び4の比較(自然科学編)

概要

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The sizes of introns 4 of the human, Japanese monkey, cat, porcine, mouse and rat DLST genes were 127, 122, 128, 111, 150, 111 and 127bp, respectively. The sizes of introns 1 of the human, Japanese monkey, cat, porcine, mouse and rat DLST genes were 568, 571, 568, 562, 531 and 514bp, respectively. The nucleotide sequences of introns 4 of the DLST genes between human and Japanese monkey of the primate and between mouse and rat of the rodent were 90% and 80% homologous, respectively. The nucleotide sequence of intron 4 of the human DLST gene was 83% homologous to that of the rat DLST gene. The sequence of intron 4 of the human DLST gene was 83%, 66% and 66% homologous to the sequences of introns 4 of the rat, cat, and porcine DLST genes, respectively. The homology between the nucleotide sequences of introns 4 of the primate and rodent DLST genes was higher than that among the primate, cat and porcine. The sequence of intron 1 of the human DLST gene was 84%, 70% and 75% homologous to those of the introns 1 of the Japanese monkey, cat and porcine DLST genes, respectively. Thus, the nucleotide sequences of the introns 1 and 4 were significantly homologous among the six mammalian DLST genes, but no homologous sequence was found in the other introns. Possibly, the introns 1 and 4 contribute to the selective splicing of the DLST gene in the physiological role.
2006-02-28