Design and Synthesis of Cinanserin Analogs as Severe Acute Respiratory Syndrome Coronavirus 3CL Protease Inhibitors
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概要
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The severe acute respiratory syndrome (SARS) coronavirus 3CL protease is an attractive target for the development of anti-SARS drugs. In this paper, cinanserin (1) analogs were synthesized and tested for the inhibitory activities against SARS-coronavirus (CoV) 3CL protease by fluorescence resonance energy transfer (FRET) assay. Four analogs show significant activities, especially compound 26 with an IC_<50> of 1.06μM.
- 2008-10-01
著者
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YANG Qingang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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CHEN Lili
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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HE Xuchang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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GAO Zhenting
School of Pharmacy, East China University of Science and Technology
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SHEN Xu
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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BAI Donglu
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Shen Xu
Drug Discovery And Design Center State Key Laboratory Of Drug Research Shanghai Institute Of Materia
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Chen Lili
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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He Xuchang
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Bai Donglu
中華人民共和国
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Bai Donglu
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Yang Qingang
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Gao Zhenting
School Of Pharmacy East China University Of Science And Technology
関連論文
- Design and Synthesis of Cinanserin Analogs as Severe Acute Respiratory Syndrome Coronavirus 3CL Protease Inhibitors
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