Development and In Vitro Evaluation of Transdermal Matrix Films of Metoprolol Tartate
スポンサーリンク
概要
- 論文の詳細を見る
The transdermal matrix films of metoprolol tartrate (MT) were prepared by casting on mercury substrate employing different ratios of polymers, ethyl cellulose (EC) and polyvinyl pyrrolidone (PVP), using dibutyl phthalate (DBT) as a plasticizer. Four formulations were prepared. Formulations MF-1, MF-2, MF-3 and MF-4 were composed of EC and PVP in the following ratios: 4.5:0.5, 4:1, 3:2 and 2:3 respectively. The formulations were subjected to various physical characterization studies namely, thickness, weight variation, drug content, moisture uptake, in vitro drug release and in vitro skin permeation. The in vitro permeation studies were carried out across excised porcine ear skin using Franz diffusion cell. Cumulative amounts of the drug released in 24 hours from the four formulations were 69.58%, 96.13%, 98.85% and 99.60%, respectively. Corresponding values for the cumulated amounts of drug permeated across the porcine skin for the above matrix films were 124.38, 153.22, 156.46 and 163.25μg/cm^2 respectively. By fitting the data into zero order, first order and Higuchi model, it was concluded that drug release from matrix films followed Higuchi model (r^2=-0.9147-0.9823), and the mechanism of release was diffusion mediated. Based on the physical evaluation, in vitro drug release & permeation characteristics, it was concluded that for potential therapeutic use, monolithic drug matrix films MF-3, composed of EC: PVP (3:2), may be suitable for the development of a transdermal drug delivery system of MT.
- 公益社団法人日本薬学会の論文
- 2008-09-01
著者
-
Dhake Avinash
L. B. Rao Institute Of Pharmaceutical Education And Research
-
Dhake Avinash
L. B. Rao Inst. Of Pharmaceutical Education And Res.
-
Khar Roop
Faculty Of Pharmacy Jamia Hamdard
-
Mishra Dina
Department Of Pharmaceutical Sciences Guru Jambheshwar University Of Science And Technology
-
Mishra Dina
Department Of Pharmaceutical Sciences Guru Jambhesh War University
-
BHATT Dinesh
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology
-
Bhatt Dinesh
Department Of Pharmaceutical Sciences Guru Jambheshwar University Of Science And Technology
関連論文
- Effect of Formulation Factors on In Vitro Permeation of Diclofenac from Experimental and Marketed Aqueous Eye Drops through Excised Goat Cornea
- A QSAR Approach for the Prediction of Stability of Benzoglycolamide Ester Prodrugs
- Spray Dried Excipient Base : A Novel Technique for the Formulation of Orally Disintegrating Tablets
- Preparation and Evaluation of Solid Dispersion of Meloxicam with Skimmed Milk
- Development and In Vitro Evaluation of Transdermal Matrix Films of Metoprolol Tartate
- Preparation, Characterization and In vitro Dissolution Studies of Solid Dispersion of Meloxicam with PEG 6000
- Preparation, Characterization and in Vitro Dissolution Studies of Solid Systems of Valdecoxib with Chitosan
- Investigations on Analgesic, Anti-inflammatory and Ulcerogenic Potential of Meloxicam Solid Dispersion Prepared with Skimmed Milk
- Formulation, Optimization, in Vivo Pharmacokinetic, Behavioral and Biochemical Estimations of Minocycline Loaded Chitosan Nanoparticles for Enhanced Brain Uptake