Preparation, Characterization and In vitro Dissolution Studies of Solid Dispersion of Meloxicam with PEG 6000
スポンサーリンク
概要
- 論文の詳細を見る
The poor solubility and wettability of meloxicam leads to poor dissolution and hence showing variations in bioavailability. The present study is aimed to increase solubility and dissolution of the drug using solid dispersion techniques. The solid binary systems were prepared at various drug concentrations (5-40%) with polyethylene glycol 6000 by different techniques (physical mixing, solvent evaporation). The formulations were characterized by solubility studies, differential scanning calorimetry, fourier transform infrared spectroscopy and in vitro dissolution rate studies. The solubility of drug increased linearly with increase in polymer concentration showing A_L type solubility diagrams. Infrared spectroscopy studies indicated the possibility of hydrogen bonding with polymer. The differential scanning calorimetry and powder X ray diffraction demonstrated the presence of polymer as eutectica or monotectica in solid dispersion along with the physical characteristics of the drug (crystalline, amorphous or a mixture of both). The solid dispersions of the drug demonstrated higher drug dissolution rates than physical mixtures and pure meloxicam, as a result of increased wettability and dispersibility of drug in a solid dispersion system.
- 公益社団法人日本薬学会の論文
- 2006-08-01
著者
-
Mishra Dina
Department Of Pharmaceutical Sciences Guru Jambhesh War University
-
Vijaya Kumar
Department Of Aerospace Engineering Tokyo Metropolitan University
関連論文
- Spray Dried Excipient Base : A Novel Technique for the Formulation of Orally Disintegrating Tablets
- Preparation and Evaluation of Solid Dispersion of Meloxicam with Skimmed Milk
- Development and In Vitro Evaluation of Transdermal Matrix Films of Metoprolol Tartate
- Preparation, Characterization and In vitro Dissolution Studies of Solid Dispersion of Meloxicam with PEG 6000
- Preparation, Characterization and in Vitro Dissolution Studies of Solid Systems of Valdecoxib with Chitosan
- Investigations on Analgesic, Anti-inflammatory and Ulcerogenic Potential of Meloxicam Solid Dispersion Prepared with Skimmed Milk
- Containerless Solidification of LuFeO_3 Melts using an Aerodynamic Levitator
- Application of Linear and Nonlinear Equalization Methods for Holographic Data Storage
- Two-Dimensional Equalization and Error Correction Using Low Density Parity Check Codes for Holographic Data Storage
- Formulation, Optimization, in Vivo Pharmacokinetic, Behavioral and Biochemical Estimations of Minocycline Loaded Chitosan Nanoparticles for Enhanced Brain Uptake