Effect of Formulation Factors on In Vitro Permeation of Diclofenac from Experimental and Marketed Aqueous Eye Drops through Excised Goat Cornea

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概要

• 論文の詳細を見る

• The effect of formulation factors on permeation of diclofenac from some experimental and marketed aqueous eye drops through excised goat cornea was evaluated. Raising the pH of formulation from 6.0 to 8.0 or diclofenac concentration from 0.05 to 0.15% (w/v) or adjusting tonicity with mannitol or addition of viscolizing agent decreased apparent permeability coefficient (Papp). Formulation (pH 7.4) containing sodium metabisulfite or EDTA or combination of methyl and propyl paraben showed significantly (p<0.05) higher Papp whereas benzalkonium chloride (BAC) had no effect and sorbic acid (SA) had reduced permeation. Surprisingly marketed drops containing BAC or SA, showed significantly (p<0.05) higher Papp and decreased in the order of Difen>Voveran>NSAID>Dicol>Diclolab. Lower pH (7.1-7.3) and surface tension of drops indicating presence of surfactant, could mediate increased permeation and presence of buffer could cause irritation on in vivo instillation. The marketed formulations showed corneal hydration >83% suggesting corneal damaging potential.

• 社団法人日本薬学会の論文
• 2006-12-01

著者

• AHUJA Munish

  Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology

• Ahuja Munish

  Department Of Pharmaceutical Sciences Guru Jambheshwar University Of Science And Technology

• Majumdar Dipak

  Dep. Of Pharmaceutics Delhi Inst. Of Pharmaceutical Sciences And Res. Formerly Coll. Of Pharmacy (un

• MAJUMDAR Dipak

  Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, (University o

• DRAKE Avinash

  L. B. Rao Institute of Pharmaceutical Education and Research

• Dhake Avinash

  L. B. Rao Inst. Of Pharmaceutical Education And Res.

関連論文

• Stability Studies on Aqueous and Oily Ophthalmic Solutions of Diclofenac
• In Vitro Corneal Permeation of Diclofenac from Oil Drops
• Effect of Formulation Factors on In Vitro Permeation of Diclofenac from Experimental and Marketed Aqueous Eye Drops through Excised Goat Cornea
• A QSAR Approach for the Prediction of Stability of Benzoglycolamide Ester Prodrugs
• Development and In Vitro Evaluation of Transdermal Matrix Films of Metoprolol Tartate

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