In Vitro Corneal Permeation of Diclofenac from Oil Drops

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概要

• 論文の詳細を見る

• In vitro transcorneal permeation of diclofenac from oil drops was studied using freshly excised goat cornea. The maximum apparent corneal permeability coefficient (Papp) was obtained with 0.2% (w/v) diclofenac drops in sesame oil followed by safflower oil, while formulation in castor oil provided minimal Papp. The addition of benzyl alcohol, a preservative, in oil drops, increased the Papp value of diclofenac. Partition experiments indicated increased partitioning of diclofenac in the aqueous phase in the presence of benzyl alcohol, and the same could be responsible for the benzyl alcohol-induced increase in Papp. The solubility of diclofenac was higher in castor, arachis, and sunflower oil. But drug permeation from 0.5-1.0% (w/v) diclofenac drops in castor oil or 0.5% (w/v) drops in arachis/sunflower oil was less than that observed with 0.2% (w/v) drops in sesame oil. Thus diclofenac 0.2% (w/v) drops in sesame oil containing 0.5% (v/v) benzyl alcohol provides maximum Papp. The formulation increased corneal hydration indicating corneal damage. Since corneal hydration is less than 83% the damage appears to be reversible. The saturation solubility of diclofenac in sesame oil at 4℃ is 0.33% (w/v). Hence diclofenac 0.2% (w/v) solution in sesame oil will not precipitate at 4℃ and therefore the chances of crystallization of diclofenac from the formulation due to climatic change leading to physical instability appear to be remote.

• 社団法人日本薬学会の論文
• 2007-10-01

著者

• AHUJA Munish

  Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology

• SHARMA Surendra

  Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology

• Ahuja Munish

  Department Of Pharmaceutical Sciences Guru Jambheshwar University Of Science And Technology

• Majumdar Dipak

  Dep. Of Pharmaceutics Delhi Inst. Of Pharmaceutical Sciences And Res. Formerly Coll. Of Pharmacy (un

• Majumdar Dipak

  Department Of Pharmaceutics Delhi Institute Of Pharmaceutical Sciences And Research:formerly College

• MAJUMDAR Dipak

  Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, (University o

• Sharma Surendra

  Department Of Pharmaceutical Sciences Guru Jambheshwar University Of Science And Technology

• SHARMA Surendra

  Department of Chemistry, D.A. V. (P.G.) College

関連論文

• Stability Studies on Aqueous and Oily Ophthalmic Solutions of Diclofenac
• In Vitro Corneal Permeation of Diclofenac from Oil Drops
• Effect of Formulation Factors on In Vitro Permeation of Diclofenac from Experimental and Marketed Aqueous Eye Drops through Excised Goat Cornea
• Enteric Microsphere Formulations of Papain for Oral Delivery
• Synthesis of Some New2-Sulphanilamidothiazoles as Potential Fungicides

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