Relationship between serum aconitines level and clinical features of aconite poisoning
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概要
- 論文の詳細を見る
トリカブト植物は主に根にアコニチン類(アコニテン,メサコニチン,ヒパコニチンやジョサコニチン)のような毒性の高いジエステル,ジテルペンタイプアコニチンアルカロイドを含有する非常に危険な植物である。アコニチン類は死に至る重篤な不整脈を生じる急性毒性の高いものとして知られている。著者らは事故で生じたトリカブト中毒患者13名の致死的な症状を記した。全ての患者は根或いは葉を摂取後15〜30分以内に特徴的なトリカブト中毒症状を呈した。これらの患者では心室頻脈や心室細勤等の不整脈が観察され,患者の1名は死亡した。著者らはこれら患者13名中5名におけるアコニチン類の血中濃度と不整脈消失の関係を検討した。消失に要する時間が各々で大きく異なるにも関わらず患者の不整脈消失時のアコニチン類血中濃度は0.5〜1.5 ng/mL であった。アコニチン類の血中濃度はトリカブト中毒患者の不整脈治療に対して重要である。従って,我々の結果はトリカブト中毒患者の今後の治療を行う上で有益な情報となるだろう。
- 2008-07-20
著者
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藤田 友嗣
岩手医科大学医学部附属病院薬剤部
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ENDO Shigeatsu
Department of Critical Care Medicine, Iwate Medical University
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藤田 友嗣
Poisoning And Drug Laboratory Division Critical Care And Emergency Center Iwate Medical University H
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藤田 友嗣
岩手医科大学高度救命救急センター薬物毒物検査部門
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Endo Shigeatsu
Department Of Critical Care Medicine Iwate Medical University
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Endo Shigeatsu
Department Of Emergency Medicine Iwate Medical University School Of Medicine
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TERUI Katsutoshi
Department of Emergency Medicine, Iwate Medical University School of Medicine
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AOKI Hidehiko
Department of Emergency Medicine, Iwate Medical University School of Medicine
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TAKEI Masao
Poisoning and Drug Laboratory Division, Critical Care and Emergency Center, Iwate Medical University
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Takei Masao
Poisoning And Drug Laboratory Division Critical Care And Emergency Center Iwate Medical University H
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Terui Katsutoshi
Department Of Emergency Medicine Iwate Medical University School Of Medicine
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Terui Katsutoshi
Department Of Critical Care Medicine Iwate Medical University
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Aoki Hidehiko
Department Of Emergency Medicine Iwate Medical University School Of Medicine
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Aoki Hidehiko
Department Of Critical Care Medicine Iwate Medical University
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