Plasma Atrial Natriuretic Factor in Patients with Acute Myocardial Infarction.
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概要
- 論文の詳細を見る
To examine whether atrial natriuretic factor (ANF) is secreted adequately in the early phase of myocardial infarction, plasma ANF concentration and clinical parameters, including hemodynamic variables, were studied in 118 patients with acute myocardial infarction (AMI). The patients were divided into 2 subgroups according to the absence (group A, n=41) or presence (group B, n=77) of a history of valvular heart disease, previous myocardial infarction, hypertension, or renal failure. Although no significant difference in atrial pressure after the infarction was found between the 2 groups, the plasma ANF level was significantly lower in group A than in group B (76±6vs. 185±26pg/ml; mean±SEM, p<0.01). Plasma ANF was correlated with pulmonary capillary wedge pressure in group B (r=0.54, p<0.001), whereas no relationship with hemodynamic parameters was observed in group A. In 56 of the 118 patients (group A, n=18; group B, n=38), the pulmonary arterial plasma level was significantly higher in group A (p<0.05), whereas the difference was not significant in group B. Seven of the 8 expired cases among these 56 patients had peripheral plasma ANF levels of more than 150pg/ml, which were higher than those in pulmonary arterial plasma.These observations suggest firstly that the plasma level of ANF is lower in patients with a new onset of myocardial infarction compared to those with a history of cardiac or renal diseases, and secondly that stimulated ANF release originates not only from the right side of the heart, but also from additional site(s), particularly in patients with chronic ventricle overload and a poor prognosis.
- International Heart Journal刊行会の論文
著者
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CHIBA Makoto
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hok
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Hiramori Katsuhiko
Department Of Cardiology Iwate Medical University
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Arakawa Naoshi
Department of Cardiology, Hannover Medical School
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Aoki Hidehiko
Department Of Critical Care Medicine Iwate Medical University
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Nakamura Motoyuki
Department Of Internal Medicine (cardiology Division) Iwate Medical University
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Yoshida Hiroaki
Department Of Aeronautics And Astronautics Graduate School Of Engineering Kyoto University
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CHIBA Makoto
Department of Medicine II, Iwate Medical University
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HIRAMORI Katsuhiko
Department of Medicine II, Iwate Medical University
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AOKI Hidehiko
Department of Medicine II, Iwate Medical University
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