Sequential and Quantitative Analysis of a Murine Model of Elastase-Induced Emphysema(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
Emphysema, one of chronic obstructive pulmonary disease (COPD), is characterized as destruction of airway wall and small airway inflammation. To assess the kinetics of disease progression in murine model of elastase-induced emphysema, we used micro-computed tomography (CT) compared with morphological changes. Two week after elastase administration, a significant increase in the volume of low-density areas, recognized as -800_-600 Hounsfield units by micro-CT, was observed. Coefficient of correlation between mean linear intercept (Lm) and low-density area examined by CT, was 0.79 (p<0.01). Micro-CT can quantitatively and sequentially detect murine emphysematous changes, offering a practical method to sequentially analyze the therapeutic effects of treatments in a murine model of emphysema.
- 公益社団法人日本薬学会の論文
- 2008-07-01
著者
-
Matsuo Yukiko
Department Of Chemistry Graduate School Of Science Osaka University
-
Matsuo Yukiko
Department Of Pharmatherapy Research Institute Of Pharmaceutical Sciences Musashino University
-
Nagase Takahide
Department Of Pulmonary Medicine Faculty Of Medicine University Of Tokyo
-
Nagase Takahide
Department Of Geriatric Medicine Graduate School Of Medicine The University Of Tokyo
-
Yamashita Naomi
Department Of Medicine Teikyo University School Of Medicine
-
Yamashita Naomi
Department Of Pharmatherapy Research Institute Of Pharmaceutical Sciences Musashino University
-
KAWAKAMI Masaki
Department of Pharmatherapy, Research Institute of Pharmaceutical Sciences, Musashino University
-
YOSHIURA Kenta
Department of Pharmatherapy, Research Institute of Pharmaceutical Sciences, Musashino University
-
Yoshiura Kenta
Department Of Pharmatherapy Research Institute Of Pharmaceutical Sciences Musashino University
-
Kawakami Masaki
Department Of Pharmatherapy Research Institute Of Pharmaceutical Sciences Musashino University:depar
関連論文
- Effect of lons on Antibacterial Activity of Human Beta Defensin 2
- Recombinant E1-Deleted Adenoviral Vectors Induce Apoptosis in a Rat Airway Epithelial Mucous Goblet Cell Line
- A Diffuse Alveolar Hemorrhage in a Human T-lymphotropic Virus Type I Carrier with Acute Cerebellar Ataxia and Interstitial Pneumonitis : An Autopsy Case Report
- Molecular mechanisms underlying inflammatory lung diseases in the elderly : Development of a novel therapeutic strategy for acute lung injury and pulmonary fibrosis
- Effect of Procaterol, a β_2 Selective Adrenergic Receptor Agonist, on Airway Inflammation and Hyperresponsiveness
- Inhibitory effects of pemirolast potassium and FK506 on degranulation and IL-8 production of eosinophils
- Synthesis of 25-^C-Amphotericin B Methyl Ester : A Molecular Probe for Solid-state NMR Measurements
- Sequential and Quantitative Analysis of a Murine Model of Elastase-Induced Emphysema(Biopharmacy)
- Yellow nail syndrome in an elderly man
- S8-3 Bronchial asthma and diesel exhaust particulates(DEP)(Effects of environmental pollution on bronchial asthma and atopic disease,English session)
- Atypical presentation of acute macular neuroretinopathy with tiny parafoveal reddish-brown lesions
- CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer
- New Cardenolides from the Seeds of Adonis aestivalis
- New Cardenolide Glycosides from the Seeds of Digitalis purpurea and Their Cytotoxic Activity
- Synthesis of 2,6-dimethyl-6-(8-methyl-4-methylene-7-nonenyl)-2-cyclohexene-1-methanols from .ALPHA.-santonin.
- Atopic NC/Nga Mice as a Model for Allergic Asthma: Severe Allergic Responses by Single Intranasal Challenge with Protein Antigen.
- Non-Infectious Bronchiolitis as an Early Pulmonary Complication of Hematopoietic Stem Cell Transplantation