Gastroprotective Mechanisms of Centipedic Acid, a Natural Diterpene from Egletes viscosa LESS.(Pharmacology)

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概要

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• This study was aimed to clarify the mechanisms of gastroprotection by centipedic acid (CPA), a natural diterpene from Egletes viscosa LESS. (Asteraceae) using ethanol-induced gastric mucosal damage in mice and gastric secretion in 4-h pylorus-ligated rats as model systems. In mice, intragastrically administered CPA (25, 50, 100 mg/kg) greatly reduced the mucosal lesions induced by 96% ethanol (0.2 ml,p.o.) by 18, 53, and 79%, respectively, whereas N-acetylcysteine (NAC, 300 mg/kg, i.p.), the reference compound produced a 50% inhibition. In 4-h pylorus-ligated rats, CPA (50 mg/kg) applied intraduodenally decreased both gastric secretory volume and total acidity. Similar to NAC, the plant diterpene effectively prevented the ethanol associated decrease in non-proteic sulfhydryls (NP-SH) and the elevated thiobarbituric acid-reactive substances (TEARS) in gastric tissue, suggesting that these compounds exert an antioxidant effect. Pretreatment of mice with indomethacin, the cyclooxygenase inhibitor but not with capsazepine, the transient receptor potential vanilloid-1 (TRPVl)-receptor antagonist greatly suppressed the gastroprotective effect of CPA. Furthermore, CPA gastroprotection was significantly attenuated in mice pretreated with L-NAME or glibenclamide the respective inhibitors of nitric oxide synthase and K^+_<ATP> channel activation. These data suggest that CPA affords gastroprotection by different and complementary mechanisms, which include a sparing effect on NP-SH reserve, and roles for endogenous prostaglandins, nitric oxide, and TRPV1-receptor and K^+_<ATP> channel activation.

• 2008-07-01

著者

• Santos Flavia

  Department Of Physiology And Pharmacology Post-graduate Programme In Medical Sciences Faculty Of Med

• Rao Vietla

  Department Of Physiology And Pharmacology Post-graduate Programme In Medical Sciences Faculty Of Med

• Rao Vietla

  Departament Of Physiology And Pharmacology Federal University Of Ceara (fm)

• Carvalho Ana

  Department Of Physiology And Pharmacology Post-graduate Programme In Medical Sciences Faculty Of Med

• Queiroz Samia

  Department Of Physiology And Pharmacology Post-graduate Programme In Medical Sciences Faculty Of Med

• Lira Silveria

  Department Of Physiology And Pharmacology Post-graduate Programme In Medical Sciences Faculty Of Med

• Silveira Edilberto

  Department Of Organic And Inorganic Chemistry Federal University Of Ceara

• Guedes Marjorie

  Department Of Physiology And Pharmacology Post-graduate Programme In Medical Sciences Faculty Of Med

• LIMA Alana

  Department of Physiology and Pharmacology, Post-Graduate Programme in Medical Sciences, Faculty of M

• Lima Alana

  Department Of Physiology And Pharmacology Post-graduate Programme In Medical Sciences Faculty Of Med

• Santos Flavia

  Departament Of Physiology And Pharmacology Federal University Of Ceara (fm)

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