Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice(Pharmacology)

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概要

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• Many natural terpenoid compounds from plants exhibit antinociceptive property but very few studies have addressed their efficacy in visceral models of nociception. The present study evaluated the antinociceptive potential of oleanolic acid, a pentacyclic triterpene in the mouse model of colonic nociception induced by mustard oil. We further examined the possible participation of opioid, α_2-adrenergic, and transient receptor potential vanil-loid 1 (TRPV1)-receptors in its mechanism. Mice were pretreated orally with oleanolic acid (3, 10, 30mg/kg) or vehicle, and the pain-related behavioral responses to intracolonic injection of mustard oil was analysed. Oleanolic acid significantly suppressed the mustard oil-induced nociceptive behaviors at test doses of 10 and 30mg/kg, in a dose-related manner. The antinociceptive effect of oleanolic acid (30mg/kg) was significantly blocked by pretreatment with the opioid antagonist, naloxone (2mg/kg, i.p.), while the α_2-adrenoceptor antagonist, yohimbine (2mg/kg, s.c.), had no effect. Pretreatment with ruthenium red (3mg/kg, s.c.), a non-competitive TRPV1 antagonist alone caused significant inhibition of mustard oil-induced nociception but its co-administration with oleanolic acid produced neither antagonism nor potentiation of oleanolic acid antinociception. In the open-field test that detects sedative or motor abnormality, mice received 30mg/kg oleanolic acid did not show any per se influence, but significantly inhibited the mustard oil-induced decrease in ambulation frequency. These data demonstrate the visceral antinociceptive potential of oleanolic acid that involves an opioid mechanism and possibly a modulatory influence on vanilloid-receptors, which needs further study.

• 公益社団法人日本薬学会の論文
• 2006-01-01

著者

• Santos Flavia

  Department Of Physiology And Pharmacology Post-graduate Programme In Medical Sciences Faculty Of Med

• Rao Vietla

  Departament Of Physiology And Pharmacology Federal University Of Ceara (fm)

• Rao Vietla

  Department Of Physiology And Pharmacology Faculty Of Medicine Federal University Of Ceara

• David Jorge

  Institute Of Chemistry Federal University Of Bahia

• Maia Juliana

  Department Of Physiology And Pharmacology Faculty Of Medicine Federal University Of Ceara

• David Juceni

  Pharmacy Faculty Federal University Of Bahia

• LIMA-JUNIOR Roberto

  Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara

• Lima-junior Roberto

  Department Of Physiology And Pharmacology Faculty Of Medicine Federal University Of Ceara

• Santos Flavia

  Departament Of Physiology And Pharmacology Federal University Of Ceara (fm)

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