Allelic Variants of Upstream Transcription Factor 1 Associate With Carotid Artery Intima-Media Thickness : The Cardiovascular Risk in Young Finns Study

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概要

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• Background Polymorphisms of the upstream transcription factor 1 (USF1) have been associated with familial combined hyperlipidemia and coronary heart disease. The impact of this gene on subclinical atherosclerosis is unknown. Associations of 3 allelic variants of the USF1 gene and their haplotypes with carotid artery intima-media thickness (IMT), carotid artery compliance (CAC) and brachial artery flow mediated dilatation (FMD) were studied in a population of Finnish healthy young adults. Methods and Results The study population comprised 2,281 individuals participating in the Cardiovascular Risk in Young Finns study. IMT, CAC and FMD values were measured by ultrasound examination. Genotypes were analysed using the 5' nuclease assay. A significant difference in IMT was found for usf1s1 (rs3737787) and usf1s8 (rs2516838) genotypes (p-values 0.046 and 0.021, respectively). Moreover, there was a significant difference between groups in haplotype 1 and haplotype 2 for IMT (p-values 0.011 and 0.028 respectively). In multivariate stepwise linear regression models adjusted by age, sex, body mass index, systolic and diastolic blood pressures, smoking, C-reactive protein, glucose, high- and low-density lipoprotein-cholesterols and triglycerides there were significant associations for the usf1s1 minor genotype AA to predict low IMT (p=0.038) and usfls8 minor genotype GG to predict high IMT (p=0.003). There was also a significant association for haplotype 2 to predict low IMT in the otherwise similar multivariate model (p=0.006). No associations were found for polymorphisms and CAC, FMD or serum lipids. Conclusions The rs2516838 and rs3737787 polymorphisms of USF1 influence the carotid artery IMT, which is a new finding.

• 2008-06-20

著者

• Collings Auni

  Department Of Clinical Chemistry Centre For Laboratory Medicine Tampere University Hospital And Tamp

• Marniemi Jukka

  Department Of Health And Functional Capacity Population Research Laboratory National Public Health I

• Raitakari Olli

  Department of Clinical Physiology, Turku University Hospital and University of Turku

• Viikari Jorma

  Department of Internal Medicine, Turku University Hospital and University of Turku

• Hoyssa Salla

  Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and Ta

• Fan Meng

  Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and Ta

• Kahonen Mika

  Department of Clinical Physiology, Tampere University Hospital

• Hutri-Kahonen Nina

  Department of Paediatrics, Tampere University Hospital

• Juonala Markus

  Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku

• Lehtimaki Terho

  Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and Ta

• Viikari Jorma

  Department Of Internal Medicine Turku University Hospital And University Of Turku

• Juonala Markus

  Research Centre Of Applied And Preventive Cardiovascular Medicine University Of Turku

• Raitakari Olli

  Department Of Clinical Physiology University Of Turku

• Raitakari Olli

  Department Of Clinical Physiology Turku University Hospital And University Of Turku

• Fan Meng

  Department Of Clinical Chemistry Centre For Laboratory Medicine Tampere University Hospital And Tamp

• Hoyssa Salla

  Department Of Clinical Chemistry Centre For Laboratory Medicine Tampere University Hospital And Tamp

• Kahonen Mika

  Department Of Clinical Physiology Tampere University Hospital

• Lehtimaki Terho

  Department Of Clinical Chemistry Centre For Laboratory Medicine Tampere University Hospital And Tamp

• Hutri-kahonen Nina

  Department Of Paediatrics Tampere University Hospital

関連論文

• Allelic Variants of Upstream Transcription Factor 1 Associate With Carotid Artery Intima-Media Thickness : The Cardiovascular Risk in Young Finns Study
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