Relation of Apolipoprotein E Polymorphism to Markers of Early Atherosclerotic Changes in Young Adults : The Cardiovascular Risk in Young Finns Study

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概要

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• Background Carotid artery intima-media thickness (IMT), which is measured by ultrasound, is used in the assessment of early atherosclerotic changes, and has been associated with apolipoprotein E (APOE) polymorphism in many studies comprising elderly subjects. However, results are still inconclusive and data relating to young adults are missing. Whether common APOE polymorphism is related to carotid IMT was studied in a population of young adults. Also brachial flow-mediated dilatation (FMD) and carotid artery compliance (CAC) were determined to clarify their relation to this genetic factor. Methods and Results A total of 1,188 young adults (aged 24-39 years) participating in the Cardiovascular Risk in Young Finns Study with complete data of common APOE polymorphism underwent a carotid and brachial ultrasound. Patients' lipid levels and blood pressure were also examined. There was no significant association between the APOE phenotypes and carotid IMT, brachial FMD or CAC either in young men or in young women. The results were similar for systolic and diastolic blood pressure. In the same population, the well-known association between APOE phenotypes and lipids was seen. Conclusions Common APOE polymorphism does not seem to be an independent genetic determinant of carotid IMT, brachial FMD or CAC.

• 社団法人日本循環器学会の論文
• 2007-12-20

著者

• Marniemi Jukka

  Department Of Health And Functional Capacity Population Research Laboratory National Public Health I

• Kahonen Mika

  Department of Clinical Physiology, Tampere University Hospital

• Hutri-Kahonen Nina

  Department of Paediatrics, Tampere University Hospital

• Viikari Jorma

  Department Of Internal Medicine Turku University Hospital And University Of Turku

• Juonala Markus

  Research Centre Of Applied And Preventive Cardiovascular Medicine University Of Turku

• Raitakari Olli

  Department Of Clinical Physiology University Of Turku

• Raitakari Olli

  Department Of Clinical Physiology Turku University Hospital And University Of Turku

• Lehtimaki Terho

  Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospita

• Gronroos Paula

  Department of Clinical Chemistry, University of Turku

• Kahonen Mika

  Department Of Clinical Physiology Tampere University Hospital

• Gronroos Paula

  Department Of Clinical Chemistry University Of Turku:laboratory Of Atherosclerosis Genetics Departme

• Lehtimaki Terho

  Department Of Clinical Chemistry Centre For Laboratory Medicine Tampere University Hospital And Tamp

• Hutri-kahonen Nina

  Department Of Paediatrics Tampere University Hospital

関連論文

• Allelic Variants of Upstream Transcription Factor 1 Associate With Carotid Artery Intima-Media Thickness : The Cardiovascular Risk in Young Finns Study
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• Apolipoprotein A-I/C-III/A-IV SstI and Apolipoprotein B Xbal Polymorphisms Do not Affect Early Functional and Structural Changes in Atherosclerosis : The Cardiovascular Risk in Young Finns Study
• Relation of Apolipoprotein E Polymorphism to Markers of Early Atherosclerotic Changes in Young Adults : The Cardiovascular Risk in Young Finns Study
• Pregnancy-Related Hyperlipidemia and Endothelial Function in Healthy Women(Clinical Investigation)
• Elaidic and trans-vaccenic acids in plasma phospholipids as indicators of dietary intake of 18:1 trans-fatty acids

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