Pregnancy-Related Hyperlipidemia and Endothelial Function in Healthy Women(Clinical Investigation)

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概要

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• Background The purpose of the present study was to investigate pregnancy-related changes in the maternal serum lipid profile and endothelial function. Methods and Results As part of the population-based, prospective cohort Cardiovascular Risk in Young Finns study conducted in Finland, 57 pregnant Finnish women and 62 control women matched for age and smoking were examined throughout gestation. Serum triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were determined and concomitantly endothelium-dependent brachial artery flow mediated dilation (FMD) was measured by ultrasound. During pregnancy serum TC, LDL-C, HDL-C, TG and very-low-density lipoprotein cholesterol increased significantly when compared with the non-pregnant state (p<0.001 for each) and towards the end of pregnancy (p<0.001, p<0.001, p=0.007, p<0.001, p<0.001). FMD increased towards the end of pregnancy and there was a statistically significant direct correlation between gestational age and FMD% (r=0.345, p=0.010). Brachial artery diameter at rest and FMD% were negatively correlated in pregnant (r=-0.280, p=0.035) and non-pregnant women (r=-0.360, p<0.004). The univariate correlation analysis showed a direct correlation between maternal serum TC (r=0.333, p=0.012) and TG (r=0.366, p=0.006) and FMD%, whereas a negative non-significant correlation was found in non-pregnant women. In a multivariate model, vessel size (β=-0.436, p=0.001) and TG (β=0.502, p<0.001) were the most powerful predictors for FMD% in pregnancy, the influence of other lipids was non-significant. Conclusions In healthy pregnant women increased gestational age is associated with improved endothelium-dependent vasodilation responses regardless of concurrently appearing lipid changes.

• 社団法人日本循環器学会の論文
• 2006-05-20

著者

• Raitakari Olli

  Department of Clinical Physiology, Turku University Hospital and University of Turku

• Juonala Markus

  Department of Internal Medicine, Turku University Hospital and University of Turku

• Viikari Jorma

  Department of Internal Medicine, Turku University Hospital and University of Turku

• Heinonen Seppo

  Department of Obstetrics and Gynaecology, Kuopio University Hospital and University of Kuopio

• Vanninen Esko

  Laboratory Centre Department Of Clinical Physiology And Nuclear Medicine Kuopio University Hospital

• Viikari Jorma

  Department Of Internal Medicine Turku University Hospital And University Of Turku

• Laitinen Tomi

  Laboratory Centre Department Of Clinical Physiology And Nuclear Medicine Kuopio University Hospital

• Laitinen Tomi

  Department Of Clinical Physiology And Nuclear Medicine Kuopio University Hospital

• Juonala Markus

  Department Of Internal Medicine Turku University Hospital And University Of Turku

• Raitakari Olli

  Department Of Clinical Physiology Turku University Hospital And University Of Turku

• Heinonen Seppo

  Department Of Obstetrics And Gynaecology Kuopio University Hospital And University Of Kuopio

• Heiskanen Nonna

  Laboratory Centre Department Of Obstetrics And Gynaecology Kuopio University Hospital And University

• Lyyra-laitinen Tiina

  Department Of Clinical Physiology Kuopio University Hospital

• Saarelainen Heli

  Department of Obstetrics Kuopio University Hospital, University of Kuopio

• Juonala Markus

  Internal Medicine, Turku University Hospital, University of Turku

• Heiskanen Nonna

  Department of Obstetrics Kuopio University Hospital, University of Kuopio

• Viikari Jorma

  Internal Medicine, Turku University Hospital, University of Turku

• Vanninen Esko

  Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, University of Ku

• Saarelainen Heli

  Department Of Obstetrics Kuopio University Hospital University Of Kuopio:department Of Gynecology Ku

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• Pregnancy-Related Hyperlipidemia and Endothelial Function in Healthy Women(Clinical Investigation)
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