100(P43) 放線菌Kibdelosporangium chichiharuensisの生産する新規マクロライド化合物について(ポスター発表の部)

概要

論文の詳細を見る
Kibdelosporangium chichiharuensis was isolated from soil in Chichiharu, China. During screening of antimicrobial activity against Bacillus subtilis, five 14-membered macrolides (1)〜(5) were found from the cultured broth of Kibdelosporangium chichiharuensis. The macrolides (1)〜(5) were purified from broth filtrate by Diaion HP-20, silica gel chromatography and HPLC. The planar structure of (1) was determined by two-dimensional NMR techniques and CI-MS. The planar structure of (2)〜(5) were determined by comparison of NMR and MS spectral data of (1). As a result, (1) and (3)〜(5) were found to be newly isolated 14-membered macrolides. The planar structure of (2) was identified with 23672 RP that was reported by Arnoux et al. Pharmacological evaluation revealed that (1) possessed higher antimicrobial activities than erythromycin A in vivo, although in vitro activities were lower. Thus (1) is a good lead compound for investigation of macrolide for further potent antibiotics.
天然有機化合物討論会の論文
1997-07-20