87 新規ホスホリパーゼA_2阻害物質、Q-6402-A,Bの構造(ポスター発表の部)

概要

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In the course of our screening program for phosphslipase A_2 (PLA_2) inhibitors, we isolated two new compounds, Q-6402-A (1) and Q-6402-B (2) from the culture broth of Streptomyces sp. Q-6402. Their structures were determined by using variety of NMR technique, and FAB-MS/MS technique. (1) was a unique cyclic peptide, consisted of 1 fatty acid and 6 amino acids. One of the amino acids was elucidated as 2-methyl-1-aminocyclopropanecarboxylic acid (MeAcc), which was a quite unusual amino acid in naturally occuring peptides. (2) had almost the same structure as (1), except the longer chain of the fatty acid moiety. (1) and (2) were found to inhibit rabit platelet PLA_2, with IC_<50> values of 19 and 6μM, respectively. In addition, (2) inhibited TPA-induced ear edema, with ED_<50> value of 121μM/ear.
天然有機化合物討論会の論文
1993-09-10