27 海洋無脊椎動物Litophyton sp.の昆虫に対する成長阻害活性成分(口頭発表の部)

概要

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It is now well established that most marine invertebrates have evolved chemical defense mechanisms that employ biologically active secondary metabolites. In our preliminary screening for biological activities of marine invertebrates, the crude extracts of a Litophyton sp. (Nephtheidae, Alcyonacea, Octocorallia) showed an insect growth inhibitory activity against the silkworm, Bombyx mori L. Monitoring the fractionations of the methanol extract by artificial diet feeding bioassay against silkworm larvae led to the isolation of eleven diterpenoids 1-11, which are responsible to the observed activity, together with two lipid metabolites 12 and 13. Their structures have been characterized by extensive 2D NMR studies, chemical methods, and molecular mechanics calculations. The absolute configuration of these diterpenoids was determined by the CD spectrum of the p-bromobenzoate 15 based on the exciton chirality method of allylic alcohol benzoate. The effective doses (ED_<50>) for 50% growth inhibition of the diterpenoids tested against silkworm larvae ranged from 1.8 to around 100 ppm.
天然有機化合物討論会の論文
1988-09-26