47 Aversion-同種のカビの異系統間拮抗現象-(および近縁種間拮抗現象)の化学的研究

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Aversion had been named by D.M. Cayley (1923) to antibiotic phenomena observed among the growing mycelia of different strains of the same species of some fungi. This is the first report chemically clarified on biologically active substances causing this phenomena, in the case of two kinds of fungi. In aversion of Cochliobolus setariae between IFO 6387 and 6635, growth inhibitory substances with selective toxicity were produced into the respective pure culture medium of each strain. The strain 6387 produced ophiobolin A (I), which inhibited the growth of the strain 6635 at 3 ppm, whereas, the former itself was not suppressed by it at 500 ppm. From the strain 6635, a dimeric bisacetal of prehelminthosporol and prehelminthosporal (IX) was isolated, which inhibited the growth of the strain 6387 at 25 ppm, and of the strain 6635 at 100 ppm. Two new metabolites were isolated from the strain 6635. Their structures were determined as cis- and trans-sativene diol (VIII and VII), respectively. In aversion of Cochliobolus lunata, a strain IFO 5997 inhibited the growth of other eight strains belonging to the same species. From the former culture filtrate, a new active substance was isolated as a methyl ester, whose structure was tentatively determined as (XIII) from spectral analysis. XIII inhibited the growth of the other strains at 3-12 ppm, whereas, of the strain 5997 at 100 ppm.
天然有機化合物討論会の論文
1974-10-01