Mechanical Stretch and Angiotensin II Increase Interleukin-13 Production and Interleukin-13 Receptor α2 Expression in Rat Neonatal Cardiomyocytes

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概要

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• Background The high affinity receptor for interleukin (IL)-13, IL-13 receptor al (IL-13Rα2), acts as a decoy receptor for IL-13, modulates fibrosis and has an anti-tumor effect. Recently, IL-13Rα2 has been considered as a therapeutic target for fibrosis and tumor growth. However, the mechanism of IL-13Rα2 expression in cardiomyocytes is unclear. Methods and Results The mechanism of IL-13Rα2 expression was examined using cultured rat neonatal cardiomyocytes. Cyclical mechanical stretch induced IL-13Rα2 mRNA expression in rat cardiomyocytes. Treatment with angiotensin II, which plays a pivotal role in mechanical stretch-induced cardiomyocyte hypertrophy, upregulated IL-13Rα2 mRNA expression in rat cardiomyocytes. IL-13Rα2 mRNA expression was also upregulated through IL-13 treatment. Furthermore, mechanical stretch and angiotensin II treatment caused IL-13 secretion from rat cardiomyocytes, which was suppressed by angiotensin typel receptor (AT1R) RNA interference. Upregulation of IL-13Rα2 mRNA expression through mechanical stretch, angiotensin II treatment and IL-13 treatment was inhibited by anti-IL-13Rα1 antibody and STAT6 depletion through RNA interference. Positive immunohistochemical staining for IL-13Rα2 was observed in the myocardium of endomyocardial biopsy specimens from the failing human heart, but not in autopsy specimens from control subjects. Conclusion IL-13 might act in an autocrine and paracrine fashion to upregulate IL-13Rα2 expression in cardiomyocytes.

• 社団法人日本循環器学会の論文
• 2008-03-20

著者

• Node Koichi

  Department Of Cardiovascular And Renal Medicine Saga University

• INOUE Teruo

  Department of Cardiovascular and Renal Medicine, Saga University

• Morooka Toshifumi

  Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine

• Nishimura Yuki

  Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine

• Inoue Teruo

  Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine

• Inoue Teruo

  Department Of Cardiovascular Medicine Dokkyo Medical University

• Inoue Teruo

  Department Of Cardiology Koshigaya Hospital Dokkyo University School Of Medicine

• Nishimura Yuki

  Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine

• Morooka Toshifumi

  Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine

• Morooka Toshifumi

  Department Of Cardiology Teikyo University Hospital

• Node Koichi

  Department Of Cardiovascular & Renal Disease Medicine Saga University

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