IL-13 Attenuates Vascular Tube Formation Via JAK2-STAT6 Pathway

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概要

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• Background Interleukin (IL)-13, which is a cytokine produced by type 2 helper T cells, has pathophysiological roles in allergic inflammation and fibrosis formation. IL-13 shares many functional properties with IL-4, which is known to inhibit angiogenesis. Methods and Results The effects of IL-13 on angiogenesis were examined using human coronary artery endothelial cells (HCAECs), in addition to investigating the mechanism(s) of this action. Using an in vitro assay of angiogenesis it was demonstrated that IL-13, as well as IL-4, significantly inhibited capillary-like tube formation. Migration of HCAECs, considered to be a process of new capillary tube formation, was also significantly inhibited by IL-13. IL-13 activated signal transduction and transcription 6 (STAT6) as a result of the activation of Janus kinase 2 (JAK2). The inhibitory effect of IL-13 on angiogenesis was abolished by depletion of JAK2 and STAT6 by RNA interference. Conclusion IL-13 has anti-angiogenic activity as a result of activation of JAK2 and subsequent activation of STAT6.

• 社団法人日本循環器学会の論文
• 2008-02-20

著者

• Node Koichi

  Department Of Cardiovascular And Renal Medicine Saga University

• INOUE Teruo

  Department of Cardiovascular and Renal Medicine, Saga University

• Nishimura Yuki

  Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine

• Inoue Teruo

  Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine

• Nitto Takeaki

  Department Of Advanced Heart Research Saga University Faculty Of Medicine

• Inoue Teruo

  Department Of Cardiovascular Medicine Dokkyo Medical University

• Inoue Teruo

  Department Of Cardiology Koshigaya Hospital Dokkyo University School Of Medicine

• Nishimura Yuki

  Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine

• Nitto Takeaki

  Advanced Heart Research, Faculty of Medicine, Saga University

• Nitto Takeaki

  Advanced Heart Research Saga University Faculty Of Medicine

• Node Koichi

  Department Of Cardiovascular & Renal Disease Medicine Saga University

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