酸化エチレン慢性曝露による貧血および赤血球グルタチオン代謝変化の回復性実験

概要

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A study was made on the recovery from anemia induced by chronic exposure of ethylene oxide. When rats were exposed to ethylene oxide at a concentration of 500 ppm, 6h a day, 3d a week for 13wk, macrocytic normochromic anemia with a high reticulocyte count was observed. The hematological values were also evaluated 4 and 13wk after the end of exposure and the values were found to have already recovered at 4wk. We reported previously that anemia, induced by ethylene oxide was accompanied with a decrease in glutathione reductase activity and instability of glutathione. In this study, alterations of glutathione redox cycle after the end of exposure were examined. The recovery in the decrease of glutathione reductase was slow and the speed of recovery seemed to be dependent on the life span of erythrocytes of the rats. The decrease in glutathione content completely recovered at 4wk after the exposure. It was concluded from these observations that anemia induced by ethylene oxide is reversible.
社団法人日本産業衛生学会の論文
1992-05-20