New approaches for prevention and treatment of infl uenza virus infection by an enhancement of mucosal immunization and suppression of protease expression
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概要
- 論文の詳細を見る
Human infl uenza virus causes an annual epidemic infection. After infl uenza virus infection in the airway,infection sometimes spreads with severe neurologic complication and multiple organ failure, resulting in highmortality. In the process of viral spread from the lungs to other organs, signifi cant up-regulated trpsin was observedin various organs. Up-regulated trypsin eff ectively converted precursor of the viral envelope hemagglutinin（ HA） intoHA1 and HA2 subunits. The proteolytic activation of HA is a prerequisite for virus multiplication. Administration ofthe inhibitors of trypsin as new approaches for the treatment of infl uenza virus infection eff ectively suppressed viralmultiplication. Almost vaccines for infl uenza virus infection are administered i.m. or s.c., which induce IgG-mediatedprotection in the systemic immune compartment, but this immunization off ers insuffi cient protection on the mucosalsurface at the initial site of viral multiplication. To improve protective mucosal immunity, intranasal vaccinationhas been studied. The powerful mucosal adjuvants reported are toxin based, such as cholera toxin and Escherichiacoli heat-labile toxin, but these enterotoxins cause severe side eff ects. We recently found natural mucosal adjuvant,pulmonary surfactant, in the lungs. Intranasal administration of infl uenza vaccine combined with Surfacten, a modifi edpulmonary surfactant free of antigenic c-type lectins, induced high protective mucosal immunity in the airway andsystemic immune responses in the blood, the effi cacy of both protective immunities by Surfacten being equivalent tothose by cholera toxin. In this symposium, we reported the eff ects of Surfacten on mucosal and systemic immunities.
- 弘前大学の論文
著者
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KIDO Hiroshi
Division of Enzyme Chemistry, Istitute for Enzyme Research, University of Tsukuba
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YAMADA Hiroshi
Division of Drug Evaluation & Informatics, School of Pharmaceutical Sciences, University of Shizuoka
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OKUMURA Yuushi
Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima
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Le Quang
Division Of Enzyme Chemistry Institute For Enzyme Research The University Of Tokushima
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Kido Hiroshi
Division Of Enzyme Chemistry Institute For Enzyme Research The University Of Tokushima
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Okumura Yuushi
Division Of Enzyme Chemistry Institute For Enzyme Research The University Of Tokushima
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Kido Hiroshi
Division Of Enzyme Chemistry Institute For Enzyme Research
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Mizuno Dai
Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima
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Chida Junji
Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima
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Yano Mihiro
Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima
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Chida Junji
Division Of Enzyme Chemistry Institute For Enzyme Research The University Of Tokushima
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Mizuno Dai
Division Of Enzyme Chemistry Institute For Enzyme Research The University Of Tokushima
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Yano Mihiro
Division Of Enzyme Chemistry Institute For Enzyme Research The University Of Tokushima
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Yamada Hiroshi
Division Of Enzyme Chemistry Institute For Enzyme Research The University Of Tokushima
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