心臓血管造影剤による急性腎機能低下に対するアセチルシステインの予防効果および製剤の評価

概要

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Though N-acetylcysteine (NAC), an antioxidant, has been used to prevent radio-contrast-induced nephropathy (RCIN), the effectiveness of using it remains unclear as the results of studies regarding its protective effect have been inconsistent. Since oral solutions of NAC have an unpleasant smell and taste, we previously developed a jelly preparation of NAC and in the present study, conducted a questionnaire survey to evaluate its user friendliness. The results of the survey indicated that the jelly preparation was effective in masking the unpleasant smell and taste. We also retrospectively examined the effectiveness of NAC in protecting against RCIN. Sixteen percent of patients in our control group (n=81, no NAC) developed RCIN, whereas none of the patients in the NAC-treated group (n=67) developed it. RCIN was defined as a greater than 25% increase in serum creatinine level occurring within 48 hours of exposure to a contrast medium. The results of this study showed that NAC has a protective effect against RCIN even in patients with a high risk of renal dysfunction, including those with diabetes or hypertension as well as those in whom high osmolarity contrast media are used.
日本医療薬学会の論文
2008-01-10