Maslinic Acid Reduces Blood Glucose in KK-A^y Mice(Pharmacology)
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概要
- 論文の詳細を見る
In the present study, we have examined the hypoglycemic effect of maslinic acid (MA) in KK-A^y mice, an animal model of genetic type-2 diabetes. MA (10mg/kg body wt) reduced the blood glucose levels in KK-A^y mice at 4h after a single oral dose. KK-A^y mice receiving MA at daily dosages of 10mg/kg and 30mg/kg for 2 weeks showed a significant reduction in the blood glucose levels. Furthermore, the results also showed that MA might modulate glucose metabolism partially through reducing insulin resistance in KK-A^y mice. Taken together, MA may hold great promise as a natural therapeutic agent for treatment of type 2 diabetes.
- 社団法人日本薬学会の論文
- 2007-11-01
著者
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Liu Jun
Key Lab Of New Drugs Design And Discovery Of Liaoning Province School Of Pharmaceutical Engineering
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Duan Weigang
National Drug Screening Center China Pharmaceutical University
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LIU Jun
National Drug Screening Center, China Pharmaceutical University
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SUN Hongbin
Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University
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MU Dongyan
National Drug Screening Center, China Pharmaceutical University
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ZHANG Luyong
National Drug Screening Center, China Pharmaceutical University
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Liu Jun
National Drug Screening Center China Pharmaceutical University
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Mu Dongyan
National Drug Screening Center China Pharmaceutical University
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Sun Hongbin
Center For Drug Discovery College Of Pharmacy China Pharmaceutical University
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Zhang Luyong
National Center Of Drug Screening China Pharmaceutical University
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Zhang Luyong
National Drug Screening Center China Pharmaceutical University
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