アナフィラキシーの薬理学的研究 (第3報) : Shock時心電図所見及びSchultz-Dale反応に及ぼす中枢神経系の関係

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Guinea pigs were sensitized with diphtherial toxoid and shocked. Not a difference in the symptoms and the findings of ECG was observed between the control and the guinea pig cut the upper quadigeminal bodies, but Schultz-Dale reaction was observed to be weakened. However, the shock symptoms, ECG findings and Schultz-Dale reaction were remarkbly weakened when the bottom of the quadrigeminal bodies were cut down. These findings were also observed under the ether anaesthesia, phenobalbital, or urethane anaesthesia. When the thoracic spinal were cut down, the convulsion in anaphylaxis was only observed at upper limbs, but the findings of ECG and Schultz-Dale reaction was as same as the control. These results suggest that the main cause of death in anaphylaxis may depends upon the antigen-antibody reaction at the convulsious and vascular center. So the main cause of the death in anaphylaxis may be the fall of blood-pressure, next is the myocardial obstruction and thirdly edema in lung.
社団法人日本アレルギー学会の論文
1960-06-01