アナフィラキシーの薬理学的研究 (第2報) : 感作モルモットの生存時諸条件とSchultz-Dale反応に関する実験的研究

概要

論文の詳細を見る
The contracting or relaxing actions of the extracted intestine of the guinea pig were investigated comparing with the actions to the blood pressure. The blocking agents of sympathetic and parasympathetic nerves relaxed the isolated intestine. Atonin O, having the rising action of blood pressure, also relaxed the intestine, however, Veratrine which falls the blood pressure contracted the intestine. Thus the contracting or relaxing actions of the extracted intestine in vitro were not always parallel to the rising or falling effect of the blood pressure. The inhibiting action of the drug in anaphylacttc reaction in vitro was almost parallel to the inhibiting action of the drug in acetylcholinic contraction, and it was also parallel to the changes of ECG observed by Shimura. In other words, the anaphylactic reaction of the small intestine sensitized with diphtherial toxoid was not influenced by the blocking agents of sympathetic and parasympathetic nerves, but inhibited by chlorpromazine or antihistamines. However, the shock symptoms in vivo and Schultz-Dale reaction in the guinea pigs, extracted one side of suprarenal bodies, pretreated with chlorpromazine or anaesthetized with aether were not necessarily parallel.
社団法人日本アレルギー学会の論文
1960-06-01