Pilot Study of Short-Term Effects of a Novel Long-Acting Oral Beraprost in Patients With Pulmonary Arterial Hypertension

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概要

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• Background Oral prostacyclin analogs can improve the prognosis of patients with mild to moderate pulmonary arterial hypertension (PAH), but because they often provoke adverse effects, such as flushing and dizziness, administering the optimal dose can be difficult. Methods and Results In the present study, a novel long-acting oral beraprost (TRK-100STP: 0-360μg/day for 12 weeks) was administered to 4 patients with mild to moderate PAH. The patients tolerated the drug well with mild adverse manifestations and negligible effects on the systemic circulation. In contrast, pulmonary vascular resistance decreased by 27±12% and the 6-min walk test distance increased by 11±11%. Conclusions TRK-100STP is a novel option in the medical management of patients with PAH. (Circ J 2007; 71: 1829-1831)

• 社団法人日本循環器学会の論文
• 2007-10-20

著者

• Ohira Hiroshi

  First Department Of Medicine Hokkaido University School Of Medicine

• Atsumi Tatsuya

  Second Department Of Medicine Hokkaido University School Of Medicine

• Nishimura Masaharu

  First Department of Medicine, Hokkaido University Graduate School of Medicine

• Nishimura Masaharu

  First Department Of Medicine Hokkaido University School Of Medicine

• Tsujino Ichizo

  First Department of Medicine, Hokkaido University School of Medicine

• Ikeda Daisuke

  First Department of Medicine, Hokkaido University School of Medicine

• Sakaue Shinji

  First Department of Medicine, Hokkaido University School of Medicine

• Ishimaru Shinji

  First Department of Medicine, Hokkaido University School of Medicine

• Itoh Naofumi

  First Department of Medicine, Hokkaido University School of Medicine

• Kamigaki Mitsunori

  First Department of Medicine, Hokkaido University School of Medicine

• Atsumi Tatsuya

  Second Departments Of Medicine Hokkaido University School Of Medicine

• Ito Naofumi

  First Department Of Medicine Hokkaido University School Of Medicine

• Sakaue Shinji

  First Department Of Medicine Hokkaido University School Of Medicine

• Ikeda Daisuke

  First Department Of Medicine Hokkaido University School Of Medicine

• Tsujino Ichizo

  First Department Of Medicine Hokkaido University School Of Medicine

• Ishimaru Shinji

  First Department Of Medicine Hokkaido University School Of Medicine

• Kamigaki Mitsunori

  First Department Of Medicine Hokkaido University School Of Medicine

• Nishimura Masaharu

  First Department Of Medicine Hokkaido University Graduate School Of Medicine

関連論文

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