Uncommon Urinary Excretion Pattern of Bile Acids in Healthy Humans: Identification and Determination of 7β-Hydroxylated Bile Acid Series

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概要

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• Urinary bile acids of three volunteers without hepatobiliary diseases were analyzed using capillary column gas chromatography and gas chromatography-mass spectrometry. In addition to the usual bile acids generally detected in the urine of healthy humans, the following bile acids, so-called "unusual bile acids", were also identified: 3β,7β-dihydroxycholanoic acid, 3α,7β,12(α-trihydroxycholanoic acid and norcholic acid. In two of the three volunteers, 7β-hydroxylated bile acids, which are ursodeoxycholic acid, 3β,7β-dihydroxycholanoic acid and 3α,7β,12α-trihydroxycholanoic acid, constituted 21% and 30% of the total urinary bile acids, respectively, while in the other, they constituted about 70-88%, unexpectedly. These findings suggest that 7β-hydroxylated bile acids are present in a considerable amount even in healthy humans.

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著者

• Yamaga Nobuo

  Department Of Biochemistry Faculty Of Medicine Tottori University

• Yamaga Nobuo

  Department Of Biochemistry And *first Department Of Internal Medicine Tottori University Faculty Of

関連論文

• Analysis of Bile Acids in Urine Specimens from Healthy Humans: Detrmination of Several Bile Acids with β-Hydroxyl and Carbonyl Groups
• Uncommon Urinary Excretion Pattern of Bile Acids in Healthy Humans: Identification and Determination of 7β-Hydroxylated Bile Acid Series
• An Examination of Alkaline Hydrolyzing Conditions of Conjugated Bile Acids with Carbonyl Groups
• Utility of 19-Hydroxycholesterol as an Internal Standard Compound for the Quantitative Determination of Sterols Using Capillary Gas Chromatograph
• Internal Standard Compounds for Quantitative Determination of Bile Acids by Gas Chromatography
• Analysis of Bile Acids in Urine Specimens from Healthy Humans: Determination of Several Bile Acids with .BETA.-Hydroxyl and Carbonyl Groups.

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