ラット根尖病変におけるIL-1発現の加齢変化

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The aim of this study was to investigate the effects of aging on the expression of interleukin-1 (IL-1) and the progression of periapical lesions using young (5 week-old) and aged (1 year-old) rats. In young animals, numerous IL-1 α- and IL-1 β-expressing cells were observed adjacent to many osteoclasts that contained large cytoplasms, and consequently the peria-pical lesions tended to expand. Both IL-1 α and IL-1β were mainly expressed by macrophages. Young animals showed a significant increase in the expression of IL-1β about a tenth greater than in aged animals during the acute phase. Then, there were significantly less IL-1β-expressing cells and consequently a significant expansion of the periapical lesion was not seen during the chronic phase. However, enlarged lesions were not repaired despite the presence of numerous osteoblasts on most resorbed bone surfaces. Conversely, in aged animals, there were only a few cells expressing IL-1β within the lesions throughout the experimental period. Although a number of small osteoclasts were observed, active bone resorption was not seen around the lesions. While, IL-1α- expressing cells were observed in the lesions, the size of the lesion had gradually increased. However, active bone remodeling was not seen around the lesions. These results suggest a possibility that there are differences in the expression of IL-1 subtypes within periapical lesions between young and aged animals. This gives rise to a speculation that the types of cytokines produced in inflamed periapical tissues may vary according to aging.
福岡歯科大学学会の論文
2007-09-30

ラット根尖病変におけるIL-1発現の加齢変化

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