The Validation of Plasma Darunavir Concentrations Determined by the HPLC Method for Protease Inhibitors(Analytical Biochemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Darunavir (DRV) is a new protease inhibitor used to treat human immunodeficiency virus (HIV) type-1 The aim of this study was to validate the determination of plasma DRV concentrations using the HPLC methods a simple procedure for simultaneous determination of seven HIV protease inhibitors and efavirenz. The calibration curve was linear (range of 0.13 to 10.36μg/ml). The average accuracy ranged from 100.7 to 105.6%. Both the interday and intraday coefficients of variation were less than 6.7%, which was similar to or much lower than previously reported values by the LC/MS/MS method. It is concluded that HPLC can be used to determine plasma DRV concentrations and routinely in the clinical setting ; thus, this HPLC method enables further study of DRV pharmacokinetics in conventional hospital laboratories.
- 公益社団法人日本薬学会の論文
- 2007-10-01
著者
-
Hirano Atsushi
Department of Pharmacy, National Hospital Organization Nagoya Medical Center
-
Takahashi Masaaki
Department of Pharmacy, National Hospital Organization Nagoya Medical Center
-
Hirano Atsushi
Department Of Pharmacy National Hospital Organization Nagoya Medical Center (tokai Area Central Hosp
-
KUDAKA Yuichi
Department of Pharmacy, National Hospital Organization Nagoya Medical Center (Tokai Area Central Hos
-
OKUMURA Naoya
Department of Pharmacy, National Hospital Organization Nagoya Medical Center (Tokai Area Central Hos
-
BANNO Kazuhide
Department of Pharmacy, National Hospital Organization Nagoya Medical Center (Tokai Area Central Hos
-
KANEDA Tsuguhiro
Clinical Research Center, National Hospital Organization Nagoya Medical Center (Tokai Area Central H
-
Kudaka Yuichi
Department Of Pharmacy National Hospital Organization Nagoya Medical Center (tokai Area Central Hosp
-
Okumura Naoya
Department Of Pharmacy National Hospital Organization Nagoya Medical Center (tokai Area Central Hosp
-
Okumura Naoya
Department Of Pediatric Cardiology Chukyo Hospital
-
Banno Kazuhide
Department Of Pharmacy National Hospital Organization Nagoya Medical Center (tokai Area Central Hosp
-
Takahashi Masaaki
Department Of Orthopaedic Surgery Hamamatsu University School Of Medicine
-
Kaneda Tsuguhiro
Clinical Research Center National Hospital Organization Nagoya Medical Center (tokai Area Central Ho
-
Takahashi Masaaki
Department Of Pharmacy National Hospital Organization Nagoya Medical Center (tokai Area Central Hosp
-
Takahashi Masaaki
Department Of Applied Biological Sciences Graduate School Of Life And Environmental Sciences Osaka P
-
Hirano Atsushi
Department Of Applied Chemistry And Chemical Engineering Kagoshima Univ
-
Takahashi Masaaki
Department Of Applied Biological Chemistry Faculty Of Agriculture Osaka Prefecture University
-
Okumura Naoya
Department Of Gastroenterology And Hepatology Sakai Hospital Kinki University Faculty Of Medicine
関連論文
- High Performance Liquid Chromatography Using UV Detection for the Simultaneous Quantification of the New Non-nucleoside Reverse Transcriptase Inhibitor Etravirine (TMC-125), and 4 Protease Inhibitors in Human Plasma
- Cooperation of Photosynthetic Reaction Center of Photosystem II under Weak Light as Shown by Light Intensity-dependence of the Half-effective Dose of Atrazine
- The Solar Flare of 1992 August 17 23 : 58 Ut
- A Conventional LC-MS Method Developed for the Determination of Plasma Raltegravir Concentrations(Analytical Biochemistry)
- The Effect of Hydrocortisone on Reducing Rates of Restenosis and Target Lesion Revascularization after Coronary Stenting Less than 3 mm in Stent Diameter
- Three-dimensional display in staging hemodynamic brain ischemia for JET study : Objective evaluation using SEE analysis and 3D-SSP display
- Successful treatment of sclerosing mediastinitis with a high serum IgG4 level
- Calorie Restricted Diet and Urinary Pentosidine in Patients with Rheumatoid Arthritis
- Methotrexate reduces the levels of pentosidine and 8-hydroxy-deoxy guanosine in patients with rheumatoid arthritis
- The effect of methotrexate on bone metabolism markers in patients with rheumatoid arthritis
- Vitamin K_2 and Etidronate Therapy in the Early Period after Hip Fracture
- Longitudinal changes of biochemical markers and bone mineral density in hyperthyroid patients during antithyroid drug therapy
- The effects of nandrolone decanoate on bone mass and metabolism in ovariectomized rats with osteopenia
- Estimation of the effects of prednisolone on bone metabolism in rats by biochemical markers
- Circadian rhythm of the urinary crosslinks pyridinoline and deoxypyridinoline in normal human and involutional osteoporosis
- EFFECTS OF CULTURE CONDITIONS ON GROWTH AND PROTEASE PRODUCTION OF BACILLUS STEAROTHERMOPHILUS YG185
- Pharmacokinetics of Lopinavir after Administration of Kaletra in Healthy Japanese Volunteers(Biopharmacy)
- Prevalence of Drug-Resistant Human Immunodeficiency Virus Type 1 in Therapy-Naive Patients and Usefulness of Genotype Testing
- Functional Structure of the Oxygen-Evolving Unit of Photosystem II as Determined by Radiation Inactivation
- A Nitrite Transporter Associated with Nitrite Uptake by Higher Plant Chloroplasts
- Orbital Frustration and Resonating Valence Bond State in the Spin-1/2 Triangular Lattice LiNiO_2
- Ruthenium-catalyzed Isomerization of Alkenol into Alkanone in Water under Irradiation of Microwaves
- -205-EFFECT OF ADENOSINE-5'-TRIPHOSPHATE ON ATRIOVENTRICULAR REENTRANT TACHYCARDIA IN INFANCY AND CHILDHOOD
- Ruthenium Catalyzed Deuterium Labelling of α-Carbon in Primary Alcohol and Primary/Secondary Amine in D_2O
- Hemodializability of Pimobendan and Its Active Metabolite, UD-CG 212, in Patients with Congestive Heart Failure Undergoing Hemodialysis
- li1-xNi1+xO2(x-0.03)の磁性とスピングラス的挙動
- Molecular Structure of a High-Potential Form of Thylakoid Cytochrome b-559 as Determined by Radiation Inactivation
- The Validation of Plasma Darunavir Concentrations Determined by the HPLC Method for Protease Inhibitors(Analytical Biochemistry)
- Determination of Plasma Tenofovir Concentrations Using a Conventional LC-MS Method(Analytical Biochemistry)
- Conventional HPLC Method Used for Simultaneous Determination of the Seven HIV Protease Inhibitors and Nonnucleoside Reverse Transcription Inhibitor Efavirenz in Human Plasma(Analytical Biochemistry)
- Beneficial Effect of GB Virus C Co-Infection in Human Immunodeficiency Virus Type 1-Infected Individuals
- A Simple HPLC Method for Simultaneous Determination of Lopinavir, Ritonavir and Efavirenz
- Percutaneous Bowel Drainage for Jaundice due to Afferent Loop Obstruction Following Pancreatoduodenectomy: Report of a Case
- Evaluation for transvaginal and transgastric NOTES cholecystectomy in human and animal natural orifice translumenal endoscopic surgery
- Dystonic Posturing Associated with Putaminal Hyperperfusion Depicted on Subtraction SPECT
- Quantitative SNP-Detection Method for Estimating HIV-1 Replicative Fitness : Application to Protease Inhibitor-Resistant Viruses
- Delayed HIV-1 Infection of CD4^+ T Lymphocytes from Therapy-Naive Patients Demonstrated by Quantification of HIV-1 DNA Copy Numbers
- A case of femoral neck fracture in a patient with severe testosterone deficiency
- Reduced order model predictive control with disturbance attenuation
- An Alternative Electron Transfer Pathway Mediated by Chloroplast Envelope
- Hepatocyte growth factor stimulates the growth of hepatocytes in altered foci and hyperplastic nodules induced by chemical hepatocarcinogens in rats
- Rendezvous gastrotomy technique using direct percutaneous endoscopic gastrostomy for transgastric cholecystectomy in hybrid natural orifice translumenal endoscopic surgery
- Levels of Mature Cross-Links and Advanced Glycation End Product Cross-Links in Human Vitreous
- Relationship between Glycoxidation and Cytokines in the Vitreous of Eyes with Diabetic Retinopathy
- Selection of Human Immunodeficiency Virus Type 1 Variants with an Insertion Mutation in the p6^ and p6^ Genes under Highly Active Antiretroviral Therapy
- The Role of Contrast Enhanced MRI in the Diagnosis of Non-Mass Image-Forming Lesions on Breast Ultrasonography
- Geodesics of Sound Waves and Their Wave Fronts in Curved Space-Time : Astrophysics and Relativity
- Prevalence of Infection and Genotypes of GBV-C/HGV among Homosexual Men
- Electron Temperature of Solar Flares Derived from Helium-Like Sulphur Lines
- B-61. Steroid Therapy of Chronic Subdural Hematoma
- Improvement of nitrate- and nitrite-dependent growth of rice by the introduction of a constitutively expressing chloroplastic nitrite transporter
- Brain damage caused by severe fetomaternal hemorrhage
- Non-bleeding Treatment for the Chronic Subdural Haematoma : The Preliminary Report
- Novel Synthesis of Natural Pseudo-aminosugars, (+)-Valienamine and (+)-Validamine
- The First Total Synthesis of Pyralomicin 1c
- Novel Synthesis of (+)-4-Acetoxy-3-hydroxyethyl-2-azetidinone from Carbohydrate A Formal Total Synthesis of (+)-Thienamycin
- Angular Momentum Transport from a Rotating Black Hole via Magnetohydrodynamical Accretion(Poster)
- Sedimentation Analysis of the State of Aggregation of the Oxygen-Evolving Photosystem II Reaction Center Core Complex and the Extrinsic Proteins
- UTILIZATION OF N-FERTILIZERS BY TRANSGENIC JAPONICA RICE EXPRESSING CUCUMBER NITRITE TRANSPORTER (CsNitr1)
- Alendronate and Raloxifene Therapy in the Early Period after Hip Fracture
- Nitrate Removal Efficiency and Bacterial Community Dynamics in Denitrification Processes Using Poly (L-lactic acid) as the Solid Substrate
- The degree of osteoporosis in patients with vertebral fracture and patients with hip fracture: Relationship to incidence of vertebral fracture
- Quantification of tumor vascularity with contrast-enhanced ultrasound for early response of transcatheter arterial chemoembolization for hepatocellular carcinoma : a report of three cases
- Trans-Fast MHD Winds in a Pulsar Magnetosphere
- Angular Momentum Transport from a Rotating Black Hole via Magnetohydrodynamical Accretion(Poster)
- Water-Stable Lithium Electrode and Its Application in Aqueous Lithium/Air Secondary Batteries
- Study of Degradation Processes of Carbon Negative Electrodes for All-solid Lithium Polymer Batteries