Determination of Plasma Tenofovir Concentrations Using a Conventional LC-MS Method(Analytical Biochemistry)

スポンサーリンク

概要

• 論文の詳細を見る

• The quantification of tenofovir, a nucleoside reverse transcriptase inhibitor prescribed once daily, in human plasma is important due to a recent increase in its use. HPLC, however, can not easily detect and quantify tenofovir because of interfering peaks. Therefore, we developed a rapid and conventional LC-MS method, validated by estimating the precision and accuracy for inter- and intraday analysis in the concentration range of 0.019-1.567μg/ml. The calibration curve was linear in the described concentration range. Average accuracy ranged from 95.9 to 100.7%. Relative standard deviations of both inter- and intraday assays were less than 11.6%. Recovery of tenofovir was more than 80.2%. This novel method provides a conventional, accurate and precise way to determine tenofovir in human plasma samples.

• 公益社団法人日本薬学会の論文
• 2007-09-01

著者

• Hirano Atsushi

  Department of Pharmacy, National Hospital Organization Nagoya Medical Center

• Takahashi Masaaki

  Department of Pharmacy, National Hospital Organization Nagoya Medical Center

• Hirano Atsushi

  Department Of Pharmacy National Hospital Organization Nagoya Medical Center (tokai Area Central Hosp

• KUDAKA Yuichi

  Department of Pharmacy, National Hospital Organization Nagoya Medical Center (Tokai Area Central Hos

• OKUMURA Naoya

  Department of Pharmacy, National Hospital Organization Nagoya Medical Center (Tokai Area Central Hos

• BANNO Kazuhide

  Department of Pharmacy, National Hospital Organization Nagoya Medical Center (Tokai Area Central Hos

• KANEDA Tsuguhiro

  Clinical Research Center, National Hospital Organization Nagoya Medical Center (Tokai Area Central H

• Kudaka Yuichi

  Department Of Pharmacy National Hospital Organization Nagoya Medical Center (tokai Area Central Hosp

• Okumura Naoya

  Department Of Pharmacy National Hospital Organization Nagoya Medical Center (tokai Area Central Hosp

• Okumura Naoya

  Department Of Pediatric Cardiology Chukyo Hospital

• Banno Kazuhide

  Department Of Pharmacy National Hospital Organization Nagoya Medical Center (tokai Area Central Hosp

• Takahashi Masaaki

  Department Of Orthopaedic Surgery Hamamatsu University School Of Medicine

• Kaneda Tsuguhiro

  Clinical Research Center National Hospital Organization Nagoya Medical Center (tokai Area Central Ho

• Takahashi Masaaki

  Department Of Pharmacy National Hospital Organization Nagoya Medical Center (tokai Area Central Hosp

• Takahashi Masaaki

  Department Of Applied Biological Sciences Graduate School Of Life And Environmental Sciences Osaka P

• Hirano Atsushi

  Department Of Applied Chemistry And Chemical Engineering Kagoshima Univ

• Takahashi Masaaki

  Department Of Applied Biological Chemistry Faculty Of Agriculture Osaka Prefecture University

• Okumura Naoya

  Department Of Gastroenterology And Hepatology Sakai Hospital Kinki University Faculty Of Medicine

関連論文

• High Performance Liquid Chromatography Using UV Detection for the Simultaneous Quantification of the New Non-nucleoside Reverse Transcriptase Inhibitor Etravirine (TMC-125), and 4 Protease Inhibitors in Human Plasma
• Cooperation of Photosynthetic Reaction Center of Photosystem II under Weak Light as Shown by Light Intensity-dependence of the Half-effective Dose of Atrazine
• The Solar Flare of 1992 August 17 23 : 58 Ut
• A Conventional LC-MS Method Developed for the Determination of Plasma Raltegravir Concentrations(Analytical Biochemistry)
• The Effect of Hydrocortisone on Reducing Rates of Restenosis and Target Lesion Revascularization after Coronary Stenting Less than 3 mm in Stent Diameter
• Three-dimensional display in staging hemodynamic brain ischemia for JET study : Objective evaluation using SEE analysis and 3D-SSP display
• Successful treatment of sclerosing mediastinitis with a high serum IgG4 level
• Calorie Restricted Diet and Urinary Pentosidine in Patients with Rheumatoid Arthritis
• Methotrexate reduces the levels of pentosidine and 8-hydroxy-deoxy guanosine in patients with rheumatoid arthritis
• The effect of methotrexate on bone metabolism markers in patients with rheumatoid arthritis
• Vitamin K_2 and Etidronate Therapy in the Early Period after Hip Fracture
• Longitudinal changes of biochemical markers and bone mineral density in hyperthyroid patients during antithyroid drug therapy
• The effects of nandrolone decanoate on bone mass and metabolism in ovariectomized rats with osteopenia
• Estimation of the effects of prednisolone on bone metabolism in rats by biochemical markers
• Circadian rhythm of the urinary crosslinks pyridinoline and deoxypyridinoline in normal human and involutional osteoporosis
• EFFECTS OF CULTURE CONDITIONS ON GROWTH AND PROTEASE PRODUCTION OF BACILLUS STEAROTHERMOPHILUS YG185
• Pharmacokinetics of Lopinavir after Administration of Kaletra in Healthy Japanese Volunteers(Biopharmacy)
• Prevalence of Drug-Resistant Human Immunodeficiency Virus Type 1 in Therapy-Naive Patients and Usefulness of Genotype Testing
• Functional Structure of the Oxygen-Evolving Unit of Photosystem II as Determined by Radiation Inactivation
• A Nitrite Transporter Associated with Nitrite Uptake by Higher Plant Chloroplasts
• Orbital Frustration and Resonating Valence Bond State in the Spin-1/2 Triangular Lattice LiNiO_2
• Ruthenium-catalyzed Isomerization of Alkenol into Alkanone in Water under Irradiation of Microwaves
• -205-EFFECT OF ADENOSINE-5'-TRIPHOSPHATE ON ATRIOVENTRICULAR REENTRANT TACHYCARDIA IN INFANCY AND CHILDHOOD
• Ruthenium Catalyzed Deuterium Labelling of α-Carbon in Primary Alcohol and Primary/Secondary Amine in D_2O
• Hemodializability of Pimobendan and Its Active Metabolite, UD-CG 212, in Patients with Congestive Heart Failure Undergoing Hemodialysis
• li1-xNi1+xO2(x-0.03)の磁性とスピングラス的挙動
• Molecular Structure of a High-Potential Form of Thylakoid Cytochrome b-559 as Determined by Radiation Inactivation
• The Validation of Plasma Darunavir Concentrations Determined by the HPLC Method for Protease Inhibitors(Analytical Biochemistry)
• Determination of Plasma Tenofovir Concentrations Using a Conventional LC-MS Method(Analytical Biochemistry)
• Conventional HPLC Method Used for Simultaneous Determination of the Seven HIV Protease Inhibitors and Nonnucleoside Reverse Transcription Inhibitor Efavirenz in Human Plasma(Analytical Biochemistry)
• Beneficial Effect of GB Virus C Co-Infection in Human Immunodeficiency Virus Type 1-Infected Individuals
• A Simple HPLC Method for Simultaneous Determination of Lopinavir, Ritonavir and Efavirenz
• Percutaneous Bowel Drainage for Jaundice due to Afferent Loop Obstruction Following Pancreatoduodenectomy: Report of a Case
• Evaluation for transvaginal and transgastric NOTES cholecystectomy in human and animal natural orifice translumenal endoscopic surgery
• Dystonic Posturing Associated with Putaminal Hyperperfusion Depicted on Subtraction SPECT
• Quantitative SNP-Detection Method for Estimating HIV-1 Replicative Fitness : Application to Protease Inhibitor-Resistant Viruses
• Delayed HIV-1 Infection of CD4^+ T Lymphocytes from Therapy-Naive Patients Demonstrated by Quantification of HIV-1 DNA Copy Numbers
• A case of femoral neck fracture in a patient with severe testosterone deficiency
• Reduced order model predictive control with disturbance attenuation
• An Alternative Electron Transfer Pathway Mediated by Chloroplast Envelope
• Hepatocyte growth factor stimulates the growth of hepatocytes in altered foci and hyperplastic nodules induced by chemical hepatocarcinogens in rats
• Rendezvous gastrotomy technique using direct percutaneous endoscopic gastrostomy for transgastric cholecystectomy in hybrid natural orifice translumenal endoscopic surgery
• Levels of Mature Cross-Links and Advanced Glycation End Product Cross-Links in Human Vitreous
• Relationship between Glycoxidation and Cytokines in the Vitreous of Eyes with Diabetic Retinopathy
• Selection of Human Immunodeficiency Virus Type 1 Variants with an Insertion Mutation in the p6^ and p6^ Genes under Highly Active Antiretroviral Therapy
• The Role of Contrast Enhanced MRI in the Diagnosis of Non-Mass Image-Forming Lesions on Breast Ultrasonography
• Geodesics of Sound Waves and Their Wave Fronts in Curved Space-Time : Astrophysics and Relativity
• Prevalence of Infection and Genotypes of GBV-C/HGV among Homosexual Men
• Electron Temperature of Solar Flares Derived from Helium-Like Sulphur Lines
• B-61. Steroid Therapy of Chronic Subdural Hematoma
• Improvement of nitrate- and nitrite-dependent growth of rice by the introduction of a constitutively expressing chloroplastic nitrite transporter
• Brain damage caused by severe fetomaternal hemorrhage
• Non-bleeding Treatment for the Chronic Subdural Haematoma : The Preliminary Report
• Novel Synthesis of Natural Pseudo-aminosugars, (+)-Valienamine and (+)-Validamine
• The First Total Synthesis of Pyralomicin 1c
• Novel Synthesis of (+)-4-Acetoxy-3-hydroxyethyl-2-azetidinone from Carbohydrate A Formal Total Synthesis of (+)-Thienamycin
• Angular Momentum Transport from a Rotating Black Hole via Magnetohydrodynamical Accretion(Poster)
• Sedimentation Analysis of the State of Aggregation of the Oxygen-Evolving Photosystem II Reaction Center Core Complex and the Extrinsic Proteins
• UTILIZATION OF N-FERTILIZERS BY TRANSGENIC JAPONICA RICE EXPRESSING CUCUMBER NITRITE TRANSPORTER (CsNitr1)
• Alendronate and Raloxifene Therapy in the Early Period after Hip Fracture
• Nitrate Removal Efficiency and Bacterial Community Dynamics in Denitrification Processes Using Poly (L-lactic acid) as the Solid Substrate
• The degree of osteoporosis in patients with vertebral fracture and patients with hip fracture: Relationship to incidence of vertebral fracture
• Quantification of tumor vascularity with contrast-enhanced ultrasound for early response of transcatheter arterial chemoembolization for hepatocellular carcinoma : a report of three cases
• Trans-Fast MHD Winds in a Pulsar Magnetosphere
• Angular Momentum Transport from a Rotating Black Hole via Magnetohydrodynamical Accretion(Poster)
• Water-Stable Lithium Electrode and Its Application in Aqueous Lithium/Air Secondary Batteries
• Study of Degradation Processes of Carbon Negative Electrodes for All-solid Lithium Polymer Batteries

もっと見る 閉じる

スポンサーリンク