Oxidative DNA Damage Estimated by Plasma 8-hydroxydeoxyguanosine (8-OHdG) : Influence of 4, 4'-methylenebis (2-chloroaniline) Exposure and Smoking

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• Oxidative DNA Damage Estimated by Plasma 8-hydroxydeoxyguanosine (8-OHdG) : Influence of 4, 4'-methylenebis (2-chloroaniline) Exposure and Smoking : Hong-I CHEN, et al. Division of Urology, Department of Surgery, Tri-Service General Hospital, Taiwan, R.O.C-Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By measuring the plasma level of 8-hydroxydeoxyguanosine (8-OHdG), we investigated the association between oxidative DNA damage and MBOCA exposure. In addition, we examined the effects of different confounders on the plasma level of 8-OHdG. We undertook a cross-sectional survey at four MBOCA-producing factories in Taiwan (158 subjects). Plasma 8-OHdG levels and urinary MBOCA concentrations were measured by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS). Personal characteristics were collected by questionnaire. The workers were classified according to their job titles as exposed (n=57) or unexposed (n=101) groups as well as classified according to urinary MBOCA levels as high urinary MBOCA (>20 μg/g creatinine) (n=45) or low urinary MBOCA (n=108) groups. Neither the MBOCA-exposed workers nor the high urinary MBOCA workers had a significant increase in the mean plasma 8-OHdG level, even after adjustment for potential confounders. Age and gender were significantly positively correlated with plasma 8-OHdG levels. Smokers among high urinary MBOCA workers also had significantly higher 8-OHdG levels than non-smokers among high urinary MBOCA workers. Our study provides evidence that smoking rather than MBOCA exposure induces elevation of plasma 8-OHdG levels among workers exposed to MBOCA, indicating that oxidative DNA damage does not play an important role in the carcinogenic processes of MBOCA.

• 社団法人日本産業衛生学会の論文

著者

• Chen Ming-fong

  Division Of Environmental Health And Occupational Medicine National Health Research Institutes

• Shih Tung-sheng

  Graduate Inst. Of Environmental Health Coll. Of Public Health China Medical Univ. And Hospital

• WU Kuen-Yuh

  Division of Environmental Health and Occupational Medicine, National Health Research Institutes

• LIOU Saou-Hsing

  Department of Public Health, National Defense Medical Center

• CHEN Hong-I

  Division of Urology, Department of Surgery, Tri-Service General Hospital

• Ho Shu-Fen

  Department of Public Health, National Defense Medical Center

• SUN Chien-Wen

  Division of Environmental Health and Occupational Medicine, National Health Research Institutes

• CHENG Li-Chuan

  Division of Environmental Health and Occupational Medicine, National Health Research Institutes

• SHIH Tung-Sheng

  Institute of Occupational Safety and Health, Council of Labor Affairs and China Medical University a

• LOH Ching-Hui

  Department of Family Medicine & Internal Medicine, Tri-Service General Hospital, National Defense Me

• Liou S‐h

  Department Of Public Health National Defense Medical Center:division Of Environmental Health And Occ

• Liou Saou-hsing

  Div. Of Environmental Health And Occupational Medicine National Health Res. Institutes

• Wu Kuen-yuh

  Division Of Environmental Health And Occupational Medicine National Health Research Institutes

• Wu Kuen-yuh

  Division Of Environmental Health And Occupational Medicine National Health

• Cheng Li-chuan

  Division Of Environmental Health And Occupational Medicine National Health Research Institutes

• Chen Hong-i

  Dep. Of Surgery National Defense Medical Center

• Loh Ching-hui

  Dep. Of Family Medicine Tri-service General Hospital National Defense Medical Center

• Chang H‐y

  Graduate Institute Of Environmental & Occupational Health National Cheng Kung University Medical

• Ho Shu-fen

  Department Of Public Health National Defense Medical Center

• Sun Chien-wen

  Division Of Environmental Health And Occupational Medicine National Health Research Institutes

• Chen Ming-fong

  Division Of Cardiology Medical Department National Taiwan University Hospital

• Shih T‐s

  Institute Of Occupational Safety And Health Council Of Labor Affairs:graduate School Of Environmenta

• Shih Tung-sheng

  Institute Of Occupational Safety And Health Council Of Labor Affairs

• Liou Saou-hsing

  Department Of Public Health National Defense Medical Center

• Shih Tung-shen

  Division Of Method Development And Analysis Institute Of Occupational Safety And Health

• Wu Kuen‐yuh

  Division Of Environmental Health And Occupational Medicine National Health Research Institutes

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