Cancer Incidence among Workers Potentially Exposed to Chlorinated Solvents in an Electronics Factory

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概要

• 論文の詳細を見る

• A retrospective cohort morbidity study based on standardized incidence ratios (SIRs) was conducted to investigate the possible association between exposure to chlorinated organic solvents and various types of cancers in an electronics factory. The cohort of the exposed group was retrieved from the Bureau of Labor Insurance (BLI) computer database records dating from 1978 through December 31, 1997. Person-year accumulation began on the date of entry to the cohort, or January 1, 1979 (whichever came later), and ended on the closing date of the study (December 31, 1997), if alive without contracting any type of cancers, or the date of death, or the date of the cancer diagnosis. Vital status and cases of cancer of study subjects were determined from January 1, 1979 to December 31, 1997 by linking cohort data with the National Cancer Registry Database. The cancer incidence of the general population was used for comparison. After adjustment for age and calendar year, only SIR for breast cancer in the exposed female employees were significantly elevated when compared with the Taiwanese general population, based on the entire cohort without exclusion. The SIR of female breast cancer also showed a significant trend of period effect, but no significant dose-response relationship on duration of employment. Although the total cancer as well as the cancer for trachea, bronchus and lung for the entire female cohort was not significantly elevated, trend analysis by calendar-year interval suggested an upward trend. However, when duration of employment or latency was taken into consideration, no significantly elevated SIR was found for any type of cancer in either male or female exposed workers. In particular, the risk of female breast cancer was not indicated to be increased. No significant dose-response relationship on duration of employment and secular trend was found for the above-mentioned cancers. This study provides no evidence that exposure to chlorinated organic solvents at the electronics factory was associated with elevated human cancers. Dominant short-term employees may bias the cancer risk toward false positive.

• 社団法人日本産業衛生学会の論文

著者

• Chang Yung-ming

  Graduate Institute Of Life Sciences National Defense Medical Center National Defense University : No

• Shih Tung-sheng

  Graduate Inst. Of Environmental Health Coll. Of Public Health China Medical Univ. And Hospital

• SHIH Tung-Sheng

  Institute of Occupational Safety and Health, Council of Labor Affairs and China Medical University a

• Shih T‐s

  Institute Of Occupational Safety And Health Council Of Labor Affairs:graduate School Of Environmenta

• Shih Tung-sheng

  Institute Of Occupational Safety And Health Council Of Labor Affairs

• TAI Chi-Fu

  Institute of Occupational Safety and Health,Council of Labor Affairs,Executive Yuan

• YANG Sweo-Chung

  Institute of Occupational Safety and Health,Council of Labor Affairs,Executive Yuan

• LIN Ruey

  College of Public Health,National Taiwan University

• SUNG Fung-Chang

  College of Public Health,National Taiwan University

• LIOU Saou-Hsing

  Graduate Institute of Life Sciences,National Defense Medical Center,National Defense University

• Liou Saou-hsing

  Graduate Institute Of Life Sciences National Defense Medical Center National Defense University : Sc

• Tai Chi-fu

  Institute Of Occupational Safety And Health Council Of Labor Affairs Executive Yuan

• Shih Tung-shen

  Division Of Method Development And Analysis Institute Of Occupational Safety And Health

• Lin R

  College Of Public Health National Taiwan University

• Yang S‐c

  Institute Of Occupational Safety And Health Council Of Labor Affairs Executive Yuan

• Sung Fung-chang

  College Of Public Health National Taiwan University

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