年齢別にみた運動負荷後の尿蛋白量

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Changes in the amount of urinary protein and β_2-microglobulin (β_2-MG) were observed after middle-distance running in 46 primary school boys, 46 junior high school boys, 74 high school boys and 51 male college students, aged between 6 and 21 years. The running distance was varied according to age : 800 m for 6- to 7-year-olds, 1,200 m for 8- to 9-year-olds, 1,700 m for 10- to 11-year-olds and 1,500 m for 12- to 21-year-olds. Urine was collected from each subject before and 30 min after running, and total urinary protein was analyzed by the Lowry method and β_2-MG by the reverse passive hemagglutination method. For all subjects at rest, total urinary protein was 14.2〜19.1 mg/dl on average and in- creased to 24.6〜96.2 mg/dl at 30 min after running, while β_2-MG at rest was 3.10〜7.12 μg/dl and increased to 30.53〜1202.87 μg/dl at 30 min after running. Urinary protein originating in blood plasma and that in non-blood plasma was calculated on the basis of the study of Poortmans(1968). Urinary protein originating in blood plasma after running was 2.54〜6.58 times higher than that before running, whereas non-blood plasma after running was 1.04〜1.92 times higher than that before running. This suggests that the increased urinary protein after running mainly originates from blood plasma. In terms of age, urinary protein from non-blood plasma in boys aged 6 to 11 years showed a greater increase than that in boys over 12 years old. The ratio of β_2-MG to urinary protein after running was 7.0〜80.6 times higher than that before running. The correlation coefficient between urinary protein and β_2-MG became higher after running than that before running. These findings indicate that low-molecular-weight urinary protein is predominantly reabsorbed in the proximal renal tubule. In terms of age, the increase in the above ratio in 12〜14-year-olds was lower than that in 15〜21-year-olds, sug- gesting that the reabsorption ability of the proximal renal tubule matures with age.
日本体力医学会の論文
1991-06-01

年齢別にみた運動負荷後の尿蛋白量

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