A Very Long-Chain Fatty Acid Elongation System in Mycobacterium avium and a Possible Mode of Action of Isoniazid on the System(Biological Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
A malonyl-CoA-dependent, acyl carrier protein (ACP)-non-requiring fatty acid elongation system was isolated from Mycobacterium avium. Chromatographical fractionation and reconstitution studies indicated that the system is composed of separable protein components like a fatty acid elongation system from M. smegmatis reported previously. In comparison of the two systems, however, some distinct features were observed in pyridine-nucleotide-coenzyme requirements and in sensitivities to isoniazid (N-amino-3-pyridine carboxylic acid amide); the system from M. avium used NADPH as a sole hydrogen donor and was inhibited by the agent, in vitro, at the concentration of 2mM, while the agent has been proved to have no inhibitory effect on the system from M. smegmatis which required both NADH and NADPH. Using the fractionated component enzymes of the system from M. avium, similar concentrations of isoniazid were found to be distinctly inhibitory against 3-oxoacyl-CoA reductase and more slightly against enoyl-CoA reductase with Ki values of 352.8μM and 5.5 mM, respectively.
- 社団法人日本農芸化学会の論文
- 1989-06-23
著者
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Kusaka T
Department Of Biochemistry Kawasaki Medical School
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Yasui Mitsukuni
Department of Applied Microbiology, Muroran Institute of Technology
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Kusaka Takashi
Department Of Biochemistry Kawasaki Medical School
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Yasui Mitsukuni
Department Of Applied Microbiology Muroran Institute Of Technology
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Kikuchi S
Department Of Applied Chemistry Muroran Lnstitute Of Technology
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Kikuchi Shintaro
Department Of Applied Chemistry Muroran Institute Of Technology
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KOLATTUKUDY Papachan
Ohio State Biotechnology Center, The Ohio State University
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Takeuchi Takao
Department Of Applied Chemistry Muroran Institute Of Technology
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Kolattukudy P
Ohio State Univ. Ohio Usa
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Kolattukudy Papachan
Ohio State Biotechnology Center The Ohio State University
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