An Anti-plasmin Inhibitor, Eckol, Isolated from the Brown Alga Ecklonia kurome OKAMURA(Biological Chemistry)

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The biological activities of eckoi, a novel phlorotannin with a dibenzo-p-dioxine skeleton, were examined. Eckol inhibited the antiplasmin activity of α_2-plasmin inhibitor very efficiently (IC_<50> ; 1.6μg/ml) as well as those of α_2-macroglobulin and α_1-antitrypsin. However, its inhibitory effect on the antithrombin III-heparin complex was very weak. Eckol also showed inhibitory activity on thrombin (IC_<50> ; 12μg/ml), but not on plasmin. Its inhibitory activity was reduced in whole human plasma, but at concentrations of above 200μg/ml it enhanced urokinase-induced fibrinolysis in human plasma. Studies on the inhibitory spectra of several derivatives of eckol showed that the dibenzo-1,4-dioxane skeleton was necessary for inhibition of plasmin inhibitor. These observations suggest that eckol or its derivatives may be useful clinically for potentiating thrombolytic activity.
社団法人日本農芸化学会の論文
1989-11-23