An α2-Macroglobulin Inhibitor, API-13782, Produced by Streptomyces canus OFR-1267

スポンサーリンク

概要

• 論文の詳細を見る

• About 7000 microbial culture filtrates have been screened for inhibition of α2-macroglobulin, one of the plasma protease inhibitors. One strain, identified as Streptomyces canus, was found to produce a potent inhibitor named API-13782. The inhibitor was purified from the culture filtrate by column chromatographies on Daiaion HP-20 and Dowex 1×2, and then by high performance liquid chromatography. API-13782 was an acidic compound of low molecular weight of, 441. It showed time-independent, fairly specific inhibition against α2-macroglobulin, and required some kinds of divalent metal ions such as Ca++, Mn++, or Co++ for development of its inhibitory action. In serum the activity of plasmin formed by urokinase, a plasminogen activator, was increased by preteatment with API-13782. This suggests that API-13782 is clinically useful as a potentiator of urokinase.

• 社団法人 日本農芸化学会の論文

著者

• Nakayama Yasuo

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Takahashi Masayuki

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• MATSUI Kuniaki

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• KATO Akira

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

関連論文

• An Anti-plasmin Inhibitor, Eckol, Isolated from the Brown Alga Ecklonia kurome OKAMURA(Biological Chemistry)
• An α2-Macroglobulin Inhibitor, API-13782, Produced by Streptomyces canus OFR-1267

スポンサーリンク