Upstream Therapy for Atrial Fibrillation(Atrial Fibrillation)
スポンサーリンク
概要
- 論文の詳細を見る
There are multiple factors for the etiology of atrial fibrillation (AF), including stretch, autonomic imbalance, hyperthyroidism, and inflammation. Of these factors for AF, stretch and inflammation increase the angiotensin II level, thereby inducing calcium over load, and inducing ectopic focal activities that initiate AF. Angiotensin II activates the Erk cascade through the AT1R and induces interstitial fibrosis of the atria, which compromises intra-atrial conduction. Short atrial refractoriness and slow conduction form multiple re-entry, before maintaining AF. Anti-arrhythmic drugs used for downstream therapy can suppress the focal activities and re-entry, but cannot prevent the development of a structural substrate. In contrast, angiotensin-converting enzyme, angiotensin n type 1 receptor blocker and statins might constitute upstream therapy through the prevention of structural remodeling that promotes AF.
- 社団法人日本循環器学会の論文
- 2007-06-20
著者
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Kumagai Koichiro
Department of Cardiology, Fukuoka University School of Medicine
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Kumagai Koichiro
Department Of Cardiology School Of Medicine Fukuoka University
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Kumagai Koichiro
Department Of 2nd Internal Medicine Fukuoka University
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