Formation of Fluorescent Substances in the Reaction of the Hydroperoxide Isomers of Methyl Linoleate and Amylamine(Biological,Chemical)

概要

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The formation of fluorescent substances through the reaction of degradation products of four geometrical isomers of methyl linoleate hydroperoxides with amylamine was studied. The 9- and 13-positional monohydroperoxide isomers having the cis-trans and trans-trans configurations were separated from autoxidized methyl linoleate by high performance liquid chromatography(HPLC) and their abilities to form fluorescent substances with amylamine in the presence of heme were compared. These four isomers produced the same fluorescent substances exhibiting excitation and emission maxima at 350 and 420nm, respectively, and also showed the same abilities for fluorescence formation and the same elution profiles of fluorescent substances (FS-I and FS-II) on HPLC. This study proved that all four geometrical isomers were involved in the production of fluorescent substances upon reaction with amino compounds.
社団法人日本薬学会の論文
1987-12-25