Syntheses and Antihypertensive Activities of 1,4-Dihydropyridine-5-phosphonate Derivatives. III(Medicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
Various 1- and 2-substituted and 1,2-fused 1,4-dihydropyridine-5-phosphonate derivatives were designed and synthesized as analogues of 1,4-dihydropyridine-3,5-dicarboxylate, and their antihypertensive activities were examined. Several compounds proved to be equal or superior to nifedipine in lowering blood pressure in normotensive and spontaneously hypertensive rats. Among these compounds, 1-substituted 1,4-dihydropyridine derivatives showed potent antihypertensive activities. The structure-activity relationships are discussed.
- 公益社団法人日本薬学会の論文
- 1987-12-25
著者
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黄瀬 正博
Research Laboratories, Nippon Shinyaku Co., Ltd.
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木村 喜代史
Research Laboratories Nippon Shinyaku Co. Ltd.
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黄瀬 正博
Nippon Shinyaku Company, Ltd.,
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黄瀬 正博
Nippon Shinyaku Company Ltd.
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冨田 敏夫
Research Laboratories Nippon Shinyaku Co. Ltd.
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森田 岩男
Research Laboratories, Nippon Shinyaku Co., Ltd.
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黄瀬 正博
Research Center Sumitomo Pharmaceuticals Co. Ltd
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津田 正己
Research Laboratories, Nippon Shinyaku Co., Ltd.
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森田 岩男
Research Laboratories Nippon Shinyaku Co. Ltd.
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春田 優子
Research Laboratories, Nippon Shinyaku Co., Ltd.
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神鳥 和久
Research Laboratories, Nippon Shinyaku Co., Ltd.
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神鳥 和久
Research Laboratories Nippon Shinyaku Co. Ltd.
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春田 優子
Research Laboratories Nippon Shinyaku Co. Ltd.
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津田 正己
Research Laboratories Nippon Shinyaku Co. Ltd.
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