Reaction of Cyclic Phosphites with Haloacetones(Organic,Chemical)
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概要
- 論文の詳細を見る
Treatment of various cyclic. phosphites (1), e.g., 2-methoxy-1,3,2-dioxaphosphorinane (la), 2-methoxy-5,5-dimethyl-1,3,2-dioxaphosphorinane (1b) and 2-methoxy-1,3,2-dioxaphosphorane (1c), with haloacetones (2) gave cyclic Arbuzov products (3), cyclic Perkow products (4), cyclic methylphosphonates (5), and acyclic products(6-8). Compound 1a gave all of the products (3a, 4a, 5a, 6ag, 7ag, 8ag). However, cyclic phosphites with substituents in the ring (1b, 1d) gave only the cyclic products (3-5). The five-membered ring phosphite (1c) yielded only the acyclic products (6cg, 7cg). Treatment of 1a with chloroacetone gave only the Perkow products (4a, 7ah). Cyclic phosphite (1f) with a 2-benzyloxy substituent afforded simply the cyclic products (3a, 4a, 9). A mechanistic interpretation of these reactions is presented.
- 公益社団法人日本薬学会の論文
- 1987-12-25
著者
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杉山 信
Research Laboratories, Nippon Shinyaku Co., Ltd.,
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黄瀬 正博
Research Laboratories, Nippon Shinyaku Co., Ltd.
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黄瀬 正博
Nippon Shinyaku Company, Ltd.,
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杉山 信
Research Laboratories Nippon Shinyaku Co. Ltd.
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黄瀬 正博
Nippon Shinyaku Company Ltd.
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森田 岩男
Research Laboratories, Nippon Shinyaku Co., Ltd.
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黄瀬 正博
Research Center Sumitomo Pharmaceuticals Co. Ltd
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津田 正己
Research Laboratories, Nippon Shinyaku Co., Ltd.
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森田 岩男
Research Laboratories Nippon Shinyaku Co. Ltd.
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津田 正己
Research Laboratories Nippon Shinyaku Co. Ltd.
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