Total Synthesis of Neolignans, Americanin A and Isoamericanin A(Organic,Chemical)
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概要
- 論文の詳細を見る
The condensation reaction of 3-benzyloxy-4-hydroxybenzaldehyde with 2,3-epoxy-3-[(3,4-dimethoxymethoxy)phenyl]-1-propanol, prepared from caffeic acid in four steps, afforded the ether (11) in good yield. Mesylation of 11 followed by treatment with potassium carbonate, provided the epoxide (13), which was converted to the debenzylation product (14) by hydrogenolysis. Compound 14 underwent cyclization with potassium carbonate to yield the trans dioxane derivative (15). Reaction of 15 with the ylide (16) followed by hydrolysis furnished americanin A (1). Isoamericanin A (3) was similarly synthesized from another condensation product (18).
- 公益社団法人日本薬学会の論文
- 1987-09-25
著者
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TANAKA Hitoshi
Faculty of Pharmacy, Meijo University
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ITO Kazuo
Faculty of Pharmacy, Meijo University
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Tanaka Hitoshi
Faculty Of Pharmacy Meijo University
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Tanaka H
Showa Univ. Tokyo Jpn
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KATO ICHIRO
Faculty of Pharmacy, Meijo University
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Kato I
Faculty Of Pharmacy Meijo University
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Ito Kazuo
Faculty Of Pharmacy Meijo University
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Kato Ichiro
Department Of Applied Physics University Of Tokyo: Fujitsu Laboratories Ltd.
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TANAKA Hitoshi
Faculty of Engineering, Tohoku University
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