Depression of Salicylamide Glucuronidation by Bacterial Lipopolysaccharide(Environmental)

概要

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The effect of lipopolysaccharide (LPS) on the urinary exeretion of salicylamide (SAM) (10mg/head) given orally to rats was examined 24h after intraperitoneal administration of LPS (0.5mg/kg) by the direct analysis of urine samples by high-performance licluid chronlirtography. The cumulative amount of SAM glucuronide excreted in urine in 4h was decreased by 40-70% in the LPS-administered rats, while that of SAM sulfate was increased by 7-15% compared with the control in the same rats. The amounts of the conjugates of gentisamide (the hydroxylated metabolite of SAM) excreted in urine were decreased by approx. 70% compared with the control. LPS administration provoked a decrease in the activities of aniline hydroxylase of liver and uridine diphosphate (UDP)-glucuronyltransferase of liver, lung and kidney, but did not change the activities of sulfotransferase of liver or UDP-glucuronyltransferase obtained from the small intestine. The mechanism of the decreased urinary excretion of SAM glucuronide in LPS-adininistered rats is discussed.
社団法人日本薬学会の論文
1987-01-25